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Synthesis of [2+1] Conjugates of Betulic Acid with α,ω-Diols

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Abstract

Three synthetic approaches to [2+1] conjugates of betulic acid with α,ω-diols have been tested. The best results have been obtained in the reaction of betulic acid with α,ω-dibromides in the presence of potassium carbonate in DMF.

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Funding

This work was financially supported by the Russian Academy of Sciences, in the framework of the “Basic Principlesof Chemistry”, topic no. 8 “Chemo-, Regio-, and Stereoselective Transformations of Terpenoids, Steroids, and Lipids in the Directed Synthesis of Low-Molecular-Weight Bioregulators” (State Reg. no. AAAA-A17-117011910023-2, 2017), using the equipment of the “Chemistry” Center for Collective Use, Ufa Institute of Chemistry, Russian Academy of Sciences, and the “Agidel” Regional Center for Collective Use, Ufa Federal Research Center, Russian Academy of Sciences.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    M. P. Yakovleva, V. A. Vydrina, R. R. Sayakhov, N. M. Ishmuratova & G. Yu. Ishmuratov

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  1. M. P. Yakovleva
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  2. V. A. Vydrina
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  3. R. R. Sayakhov
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  4. N. M. Ishmuratova
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  5. G. Yu. Ishmuratov
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Correspondence to M. P. Yakovleva.

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Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 11, pp. 1624–1632 https://doi.org/10.31857/S0514749221110082.

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Yakovleva, M.P., Vydrina, V.A., Sayakhov, R.R. et al. Synthesis of [2+1] Conjugates of Betulic Acid with α,ω-Diols. Russ J Org Chem 57, 1861–1867 (2021). https://doi.org/10.1134/S1070428021110087

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