Abstract
3-Oxo or/and 11-oxo derivatives of natural 3-hydroxy triterpenes,i.e., 3-oxoursolic acidIa, 11-oxoursolic acidIb, 3,11-dioxoursolic acidIc, 3-oxobetulinic acidIIa and 3-oxopomolic acidVIa were exhibited to show an increased anti-HSV-1 activityin vitro, four to ten times as much as corresponding parent 3-hydroxy compounds.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References Cited
Amoros, M., Fauconnier, B. and Girre, R. L.,In vitro antiviral activity of saponin fromAnagallis arvensis, Primulaceae, againstHerpes simplex virus and polio-virus.Antiviral Res., 8, 13–25 (1987).
Cheng, D. L. and Cao, X. P., Pomolic acid derivatives from the root ofSanguisorba officinalis.Phytochemistry, 31, 1317–1320 (1992).
Gonalez, A. G., Amaro, J., Fraga, B. M. and Luis, J. G., 3-oxo-6β-hydroxy-olean-18-en-28-oic acid from Orthopterygium huancuy.Phytochemistry, 22, 1828–1830 (1983).
Han, B. H., Cho, M. S., Han, Y. N. and Park, M. H., Studies on triterpenoid corticomimetics (II), Synthesis of 11-oxo-oleanolic acid derivatives and their anti-inflammatory activities.Korean Biochem. J., 17, 39–45 (1984).
Han, Y. N., Han, B. H., Park, E. T. and Kim, T. H., E-ring opening of pomolic acid by retrograde aldol condensation.Arch. Pharm. Res., 8, 221–227 (1985).
Hattori, M., Sakamoto, T., Kobashi, K. and Namba, T., Metabolism of glycyrrhizin by human intestinal flora.Planta medica, 48, 38–42 (1983).
Hirabayashi, K., Iwata, S., Matsumoto, H., Mori, T., Shibata, S., Baba, M., Ito, M., Shigeta, S., Nakashima, H. and Yamamoto, N., Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1 (HIV-1) andHerpes simplex virus type 1 (HSV-1)in vitro.Chem. Pharm. Bull., 39, 112–115 (1991).
Hu, J. M. and Hsiung, G. D., Evaluation of new antiviral agents.Antiviral Res., 11, 217–232 (1989).
Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S. and Yamamoto, N., Inhibitory effect of glycyrrhizin on thein vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV-1 (HTLV-III/LAV)].Antiviral Res., 7, 127–137 (1987).
Park, H. K., A study on the development of new pharmaceuticals from natural products. the 4th annual report on the special project issued by the Ministry of Science and Technology, Korea. p. 180–190 (1992).
Poehland, B. L., Carte, B. K., Francis, T. A., Hyland, L. J., Allaudeen, H. S. and Troupe, T. A.,In vitro antiviral activity of dammar resin triterpenoids.J. Nat. Prod., 50, 706–713 (1987).
Rao, G. S. and Cochran, K. W., Antiviral activity of triterpenoid saponins containing β-amyrin aglycones.J. Pharm. Sci., 63, 471–473 (1968).
Ryu, S. Y., Lee, C. K., Lee, C. O., Kim, H. S. and Zee, O. P., Antiviral triterpenes from Prunella vulgaris.Arch. Pharm. Res., 15, 242–245 (1992).
Siddiqui, S., Siddiqui, B. S., Begum, S. and Naeed, A., pentacyclic triterpenoids fromPlumeria obtusa Phytochemistry, 29, 3615–3620 (1990).
Sinsheimer, J. E., Rao, S. G., McIlhenny, H. M., Smith, R. V., Maassab, H. F. and Cochran, K. W., Isolation and antiviral activity of the gymnemic acids.Experientia, 24, 302–303 (1968).
Zaletova, N. I., Shchavlinskii, A. N., Tolkachev, O. N., Fateeva, T. V., Krutikova, N. M., Yartseva, I. V. and Klyuev, N. A., Preparation of some derivatives of ursolic acid and their antimicrobial activity.Khim.-Farm. Zh., 20(5), 568–571 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ryu, S.Y., Lee, C.K., Ahn, J.W. et al. Antiviral activity of triterpenoid derivatives. Arch. Pharm. Res. 16, 339–342 (1993). https://doi.org/10.1007/BF02977528
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02977528