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From Acylethynylpyrroles to Pyrrolo[1,2-a]pyrazines in One Step

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Abstract

An efficient one-step method for the synthesis of pyrrolo[1,2-a]pyrazines has been developed. The method involves the addition of propargylamine to 2-(acylethynyl)pyrroles followed by a base-catalyzed (Cs2CO3) intramolecular cyclization of the resulting N-propargyl(pyrrolyl)aminoenones.

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ACKNOWLEDGMENTS

The work was performed using the equipment of the Baikal Analytical Center for Collective Use, Siberian Branch, Russian Academy of Sciences.

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Authors and Affiliations

  1. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk, Russia

    E. F. Sagitova, L. N. Sobenina & B. A. Trofimov

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  1. E. F. Sagitova
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  2. L. N. Sobenina
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  3. B. A. Trofimov
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Correspondence to B. A. Trofimov.

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Sagitova, E.F., Sobenina, L.N. & Trofimov, B.A. From Acylethynylpyrroles to Pyrrolo[1,2-a]pyrazines in One Step. Russ J Org Chem 56, 225–233 (2020). https://doi.org/10.1134/S1070428020020082

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