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Reaction of trifluoroacetylchromenes with 6-aminouracils. Synthesis of pyrido[2,3-d]pyrimidines

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Abstract

The condensation of trifluoroacetyl-substituted 4H-chromenes and 1H-benzo[f]chromenes with 6-amino-1,3-dimethyluracil and 6-aminothiouracil afforded a number of pyrido[2,3-d]pyrimidine derivatives containing a 2-hydroxybenzyl or 2-hydroxynaphthalen-1-ylmethyl group in the 6-position as a result of cascade transformation initiated by Michael addition.

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Authors and Affiliations

  1. Samara State Technical University, ul. Molodogvardeiskaya 244, Samara, 443100, Russia

    Yu. V. Popova, D. V. Osipov, V. A. Osyanin & Yu. N. Klimochkin

  2. Russian University of Peoples’ Friendship, ul. Miklukho-Maklaya 6, Moscow, 117198, Russia

    V. A. Osyanin

Authors
  1. Yu. V. Popova
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  2. D. V. Osipov
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  3. V. A. Osyanin
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  4. Yu. N. Klimochkin
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Corresponding author

Correspondence to V. A. Osyanin.

Additional information

Original Russian Text © Yu.V. Popova, D.V. Osipov, V.A. Osyanin, Yu.N. Klimochkin, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 4, pp. 592–596.

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Popova, Y.V., Osipov, D.V., Osyanin, V.A. et al. Reaction of trifluoroacetylchromenes with 6-aminouracils. Synthesis of pyrido[2,3-d]pyrimidines. Russ J Org Chem 53, 599–603 (2017). https://doi.org/10.1134/S1070428017040169

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  • DOI: https://doi.org/10.1134/S1070428017040169

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