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Synthesis of 4-amino-6-hetarylthieno[2,3-d]pyrimidines from 5-acetyl-6-aminopyrimidine-4(3H)-thiones

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Abstract

An efficient method for the synthesis of functionalized thieno[2,3-d]pyrimidines and 2-(thieno[2,3-d]pyrimidin-6-yl)pyrido[2,3-d]pyrimidines from 5-acetyl-6-aminopyrimidine-4(3H)-thiones and a series of reagents containing an active chloromethylene fragment has been developed.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. V. Komkov, S. V. Baranin, A. S. Dmitrenok & I. V. Zavarzin

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  1. A. V. Komkov
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  2. S. V. Baranin
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  3. A. S. Dmitrenok
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  4. I. V. Zavarzin
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Correspondence to S. V. Baranin.

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Dedicated to the Academician of the Russian Academy of Sciences V. A. Tartakovsky on the occasion of his 90th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1720–1728, August, 2022.

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Komkov, A.V., Baranin, S.V., Dmitrenok, A.S. et al. Synthesis of 4-amino-6-hetarylthieno[2,3-d]pyrimidines from 5-acetyl-6-aminopyrimidine-4(3H)-thiones. Russ Chem Bull 71, 1720–1728 (2022). https://doi.org/10.1007/s11172-022-3582-3

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