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Microwave-assisted synthesis and pharmacological studies of novel 5-deazaalloxazine derivatives

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Abstract

A series of pyrimido[4,5-b]quinolin-2,4(1H,3H)-dione derivatives (5-deazaalloxazines) was synthesized by the reaction of various substituted 2-chloroquinolin-3-carboxylic acids with urea/thiourea. The structure of these newly synthesized compounds was characterized by standard spectroscopic and analytical techniques. The antimicrobial activities of the title compounds were evaluated against Gram-positive and Gram-negative bacteria and fungi using a micro dilution procedure and compared with those of standard drugs. The minimum inhibitory concentration of the derivative compounds was also determined by measuring their in vitro activities against both bacteria and fungi strains.

Graphical Abstract

Newly synthesized pyrimido[4,5-b]quinolin-2,4(1H,3H)-dione derivatives structure was elucidated on the basis of standard spectroscopic and analytical techniques. In vitro activities of title compounds were evaluated against Gram-positive, Gram-negative bacteria and fungi using micro dilution procedure.

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Acknowledgments

The financial support by the Government of Tamilnadu, India, (to author V. N.) is gratefully acknowledged. The authors thank Changwon National University, Changwon, Republic of Korea, and the Indian Institute of Technology, Chennai, India, for the spectral analyses.

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Author notes

  1. Senniappan Thamarai Selvi

    Present address: Department of Chemistry, LRG Government Arts College for Women, Tirupur, 641 604, Tamilnadu, India

Authors and Affiliations

  1. Department of Chemistry, Kongunadu Arts and Science College, Coimbatore, 641 029, Tamilnadu, India

    Vetrivel Nadaraj & Senniappan Thamarai Selvi

  2. Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences, Gandhinagar, 382 355, Gujarat, India

    Sellappan Mohan

  3. Department of Bio and Nano Chemistry, College of Natural Science, Kookmin University, 861-1 Jeongneung-dong, Seongbuk-gu, Seoul, 136 702, Republic of Korea

    Thangaian Daniel Thangadurai

Authors
  1. Vetrivel Nadaraj
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  2. Senniappan Thamarai Selvi
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  3. Sellappan Mohan
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  4. Thangaian Daniel Thangadurai
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Corresponding authors

Correspondence to Senniappan Thamarai Selvi or Thangaian Daniel Thangadurai.

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Nadaraj, V., Selvi, S.T., Mohan, S. et al. Microwave-assisted synthesis and pharmacological studies of novel 5-deazaalloxazine derivatives. Med Chem Res 21, 2911–2919 (2012). https://doi.org/10.1007/s00044-011-9811-1

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  • DOI: https://doi.org/10.1007/s00044-011-9811-1

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