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Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines

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Abstract

The rules were investigated of the regioselective synthesis of N2-substituted derivatives of 2-amino-6-benzyl-5-methylpyrimidin-4(3H)-one from 6-benzyl-5-methyl-2-(methylsulfanyl) pyrimidin-4(3H)-one.

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References

  1. Cancio, R., Mai, A., Rotili, D., Artico, M., Sbardella, G., Clotet-Codina, I., Este, J.A., Crespan, E., Zanoli, S., Hubscher, U., Spadari, S., and Maga, G., Chem. Med. Chem., 2007, vol. 2, p. 445.

    CAS  Google Scholar 

  2. Mai, A., Artico, M., Ragno, R., Sbardella, G., Massa, S., Musiu, C., Mura, M., Marturana, F., Cadeddu, A., Maga, G., and La Colla, P., Bioorg. Med. Chem., 2005, vol. 13, p. 2065.

    Article  CAS  Google Scholar 

  3. Ragno, R., Mai, A., Sbardella, G., Artico, M., Massa, S., Musiu, C., Mura, M., Marturana, F., Cadeddu, A., and La Colla, P., J. Med. Chem., 2004, vol. 47, p. 928.

    Article  CAS  Google Scholar 

  4. Manetti, F., Este, J.A., Clotet-Codina, I., Armand-Ugon, M., Maga, G., Crespan, E., Cancio, R., Mugnaini, C., Bernardini, C., Togninelli, A., Carmi, C., Alongi, M., Petricci, E., Massa, S., Corelli, F., and Botta, M., J. Med. Chem., 2005, vol. 48, p. 8000.

    Article  CAS  Google Scholar 

  5. Novakov, I.A., Orlinson, B.S., and Navrotskii, M.B., RF Patent 2 238 269, 2004.

  6. Mai, A., Artico, M., Sbardella, G., Massa, S., Loi, A.G., Tramontano, E., Scano, P., and La, Colla, P., J. Med. Chem., 1995, vol. 38, p. 3258.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Volgograd State Technical University, Volgograd, 400131, Russia

    I. A. Novakov, B. S. Orlinson, M. B. Navrotskii, E. A. Gordeeva & E. N. Savel’ev

  2. Instituto Pasteur-Fondazione Cenci Bolognetti, Dipartamento di Studi Farmaceutici, Universita degli studi di Roma “La Sapienza”, Roma, Italy

    A. Mai, M. Artico & D. Rotili

Authors
  1. I. A. Novakov
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  2. B. S. Orlinson
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  3. A. Mai
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  4. M. Artico
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  5. D. Rotili
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  6. M. B. Navrotskii
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  7. E. A. Gordeeva
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  8. E. N. Savel’ev
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Corresponding author

Correspondence to I. A. Novakov.

Additional information

Original Russian Text © I.A. Novakov, B.S. Orlinson, A. Mai, M. Artico, D. Rotili, M.B. Navrotskii, E.A. Gordeeva, E.N. Savel’eva, 2009, published in Zhurnal Organicheskoi Khimii, 2009, Vol. 45, No. 5, pp. 786–789.

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Novakov, I.A., Orlinson, B.S., Mai, A. et al. Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines. Russ J Org Chem 45, 773–776 (2009). https://doi.org/10.1134/S1070428009050212

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  • DOI: https://doi.org/10.1134/S1070428009050212

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