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New Cyanoarylporphyrazines with High Sensitivity of Photophysical Parameters to Viscosity as Promising Agents for Photodynamic Therapy

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Abstract

Photophysical properties and photodynamic activity for a series of cyanoarylporphyrazine pigments have been analyzed depending on the nature of the substituents and their position in the aromatic ring. Replacement of the fluorine atom in the para-position with the methoxy group leads to significant increase in the ratio of the dark and photoinduced cytotoxicities, i.e. potential therapeutic index of porphyrazine as photosensitizer in photodynamic cancer therapy.

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Funding

This study was financially supported by the President of Russia (grant MK-1469.2019.3, synthesis and study of properties of porphyrazine 1) and performed using the equipment of Analytical Center, Institute of Organometallic Chemistry, Russian Academy of Sciences in the scope of the state task (no. АААА-А19-119011690055-0).

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Authors and Affiliations

  1. Razuvaev Institute of Organometallic Chemistry of the Russian Academy of Sciences, 603950, Nizhny Novgorod, Russia

    S. A. Lermontova, T. S. Lyubova, E. Yu. Ladilina & L. G. Klapshina

  2. Institute of Applied Physics of the Russian Academy of Sciences, 603950, Nizhny Novgorod, Russia

    V. I. Plekhanov & L. G. Klapshina

  3. Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod, Russia

    I. V. Balalaeva

  4. St. Petersburg State University, 198504, St. Petersburg, Russia

    V. P. Boyarskii

Authors
  1. S. A. Lermontova
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  2. T. S. Lyubova
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  3. E. Yu. Ladilina
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  4. V. I. Plekhanov
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  5. I. V. Balalaeva
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  6. V. P. Boyarskii
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  7. L. G. Klapshina
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Correspondence to L. G. Klapshina.

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Lermontova, S.A., Lyubova, T.S., Ladilina, E.Y. et al. New Cyanoarylporphyrazines with High Sensitivity of Photophysical Parameters to Viscosity as Promising Agents for Photodynamic Therapy. Russ J Gen Chem 90, 249–256 (2020). https://doi.org/10.1134/S1070363220020140

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  • DOI: https://doi.org/10.1134/S1070363220020140

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