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Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

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Abstract

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Medicinal Science, University of Science and Tecnology, Taeez, Yemen

    A. H. Ahmed

  2. Chemistry Department, Faculty of Science, Arish University, Cairo, Egypt

    A. Ebead

  3. Faculty of Industrial Education, Beni Suef University, Beni Suef, Egypt

    H. Afifi

  4. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt

    A. A.-H. Abdel-Rahman

Authors
  1. A. H. Ahmed
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  2. A. Ebead
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  3. H. Afifi
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  4. A. A.-H. Abdel-Rahman
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Correspondence to A. A.-H. Abdel-Rahman.

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Ahmed, A.H., Ebead, A., Afifi, H. et al. Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives. Russ J Gen Chem 89, 357–363 (2019). https://doi.org/10.1134/S1070363219020294

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  • DOI: https://doi.org/10.1134/S1070363219020294

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