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Synthesis of some new thiazole derivatives and their cytotoxicity on different human tumor cell lines

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Abstract

Some novel 1-(inden-3-ylidene)-2-(thiazol-2-ylidene)hydrazine derivatives 3–9 were synthesized by the Hantzsch reaction of thiosemicarbazone derivatives 2a–2c with halo ketones and halo esters. Thiosemicarbazone derivatives reacted with hydrozonyl chlorides to give diazenyl-4-methylthiazole derivatives 11a–11d. Structures of the products were elucidated from IR, 1H, and 13C NMR, and Mass spectra elucidate. The synthesized compounds were screened for their cytotoxicity against three human tumor cell lines. Twenty compounds showed high (≥60 %) antiproliferative activity over breast cancer (MCF-7). Compounds 2b, 3c, 4a, 4b, 6b, 6c, 7b, 8a, and 11b possessed higher cytotoxic activity over breast tumor cell line than Doxorubicin.

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Authors and Affiliations

  1. Chemistry Department, College of Science, Aljouf University, Sakaka, Al-Jouf, 72341, Saudi Arabia

    A. M. Mohamed

  2. Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    A. M. Mohamed & N. A. Abdel-Hafez

  3. Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt

    A. F. Kassem & E. M. H. Abbas

  4. Pharmacognosy Department, Drug Bioassay-Cell Culture Laboratory, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, Egypt

    M. M. Mounier

Authors
  1. A. M. Mohamed
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  2. N. A. Abdel-Hafez
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  3. A. F. Kassem
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  4. E. M. H. Abbas
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  5. M. M. Mounier
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Correspondence to A. M. Mohamed.

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Mohamed, A.M., Abdel-Hafez, N.A., Kassem, A.F. et al. Synthesis of some new thiazole derivatives and their cytotoxicity on different human tumor cell lines. Russ J Gen Chem 87, 2391–2400 (2017). https://doi.org/10.1134/S1070363217100218

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  • DOI: https://doi.org/10.1134/S1070363217100218

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