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Synthesis of some novel S-alkylated and S-glycosylated hydantoin derivatives containing pyrene moiety

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Abstract

3-Aryl-5-[(Z)-pyrenylmethylene]-2-alkylthiohydantoins and 3-Aryl-5-[(Z)-pyrenylmethylene]-2-(D-glycosyl)-2-thiohydantoins functionalized with different aromatic and glycoside substituents have been synthesized by the reaction of (Z)-3-(4-methoxyphenyl)-5-[(pyren-8-yl)methylene]-2-thiohydantoin with alkyl halides, cyclic and acyclic nucleosides via various routes with moderate to good yields and characterized by 1H, 13C NMR and mass spectra and elemental analysis

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa, M. A. Al-Omar & A. E. Amr

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Cairo, Dokki, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

    E. S. Nossier

  4. Applied Organic Chemistry Department, National Research Centre, Cairo, Dokki, 12622, Egypt

    A. E. Amr

Authors
  1. N. M. Khalifa
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  2. E. S. Nossier
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  3. M. A. Al-Omar
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  4. A. E. Amr
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Corresponding author

Correspondence to N. M. Khalifa.

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Khalifa, N.M., Nossier, E.S., Al-Omar, M.A. et al. Synthesis of some novel S-alkylated and S-glycosylated hydantoin derivatives containing pyrene moiety. Russ J Gen Chem 86, 919–923 (2016). https://doi.org/10.1134/S1070363216040277

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  • DOI: https://doi.org/10.1134/S1070363216040277

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