Abstract
The reaction of 2-(2-acetoxyethyl)amino-4-chloro-6-methylpyrimidine with aromatic amines leads to a series of 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines. Deacetylation of these compounds proceeds in both acidic and basic media. Most of the arylaminopyrimides obtained exhibit a pronounced antituberculous effect.
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Original Russian Text © A.V. Erkin, V.I. Krutikov, 2007, published in Zhurnal Obshchei Khimii, 2007, Vol. 77, No. 11, pp. 1887–1892.
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Erkin, A.V., Krutikov, V.I. 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines: Synthesis, deacetylation, and biological activity. Russ J Gen Chem 77, 1939–1943 (2007). https://doi.org/10.1134/S1070363207110163
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DOI: https://doi.org/10.1134/S1070363207110163