Abstract
The Schiff base ligand, HL · 0.5C2H5OH (HL = methyl N-[(4-chlorophenyl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylindene)methyl]valine), was derived from condensation of 1-phenyl-3-methyl-4-(p-chlorbenzyl)-5-pyrazolone with L-valine methyl ester in a 1: 1 molar ratio in methanol, ether and isopropanol solution. Reaction of ligand with Co(ClO4)2 · 6H2O (in a 2: 1 molar ratio) in methanol solution afforded a mononuclear cobalt(II) complex, [Co(L)2] (I). Molecular structures of HL · 0.5C2H5OH and complex I were characterized by elemental analysis, IR and single crystal X-ray diffraction analysis. The enamine-keto form of the ligand has turned to imine form in complex I. Each Co(II) center in complex I is in a octahedral N2O4 coordination sphere. Both the Schiff base ligand and its Co(II) complex have been tested in vitro with agar dilution method to evaluate their antibacterial activity against bacteria Escherichia coli and Staphylococcus aureus. It has been found that they have higher activity against Escherichia coli than Staphylococcus aureus, and complex I has higher activity than HL · 0.5C2H5OH against the same bacteria.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Li, J., Li, Z., and Liu, L., Inorg. Chim. Acta, 2007, vol. 360, p. 1995.
Brana, M.F., Gradillas, A., and Ovalles, A.G., Bioorg. Med. Chem., 2006, vol. 14, p. 9.
Zhang, G.L., Dai, B.Q., and Li, J.Z., J. Inorg. Chem., 2003, vol. 19, p. 1331.
Luo, Z.M., Yu, Q., and Yang, C., Chem. Reagent, 2003, vol. 25, p. 193.
Yu, Z.G., Li, J.Z., and Liu, S.Q., Appl. Chem., 2004, vol. 21, p. 1300.
Habibi, M.H., Mokhtari, R., Harrington, R.W., and Clegg, W., Acta Crystallogr., E, 2007, vol. 63, p. 2881.
Li, D.Q. and Zhou, S., J. Guangxi Sci., 2009, vol. 16, p. 73.
Aoki, I., Takahashi, A., and Watanabek, K., Bull. Chem. Soc. Jpn., 1990, vol. 63, p. 1973.
Dutta, R.L. and Das, B.R., J. Sci. Ind. Res., 1988, vol. 47, p. 41.
Wang, C.G., Zhu, X.D., and Zhang, C.C., J. Huazhong Normal Univ., 1995, vol. 29, p. 336.
Yang, Z.Y., Ai, J., and Wang, L.F., J. Lanzhou Univ., 1993, vol. 29, p. 1620.
Patrick, D. and Prasad, P., Inorg. Chem., 2003, vol. 42, p. 7366.
Feng, X.Z., Xia, J.H., and Liu, Z., Chem. Res. Appl., 2007, vol. 19, p. 1155.
Li, J.P., Ji, Y., and Liu, R.J., Chem. Res. Appl., 2008, vol. 20, p. 87.
Casella, L. and Gullotti, M., Inorg. Chem., 1986, vol. 25, p. 1293.
Guzow, K. and Milewska, M., Tetrahedron, 2004, vol. 60, p. 11889.
Tshuva, E.Y. and Lippard, S.J., Chem. Rev., 2004, vol. 104, p. 987.
Jenson, B.S., Acta Chem. Scand., 1959, vol. 13, p. 1668.
Sheldrick, G.M., SHELXL-97, Program for X-Ray Crystal Structure Refinement, G:ottingen (Germany): Univ. of G:ottingen, 1997.
Sheldrick, G.M., SHELXL-97, Program for X-Ray Crystal Structure Solution, G:ottingen (Germany): Univ. of G:ottingen, 1997.
Yuan, Z.L., Hu, Q.H., and Wu, Q., Appl. Chem. Industry, 2008, vol. 37, p. 196.
Jing, L.X., Liu, Z., and Xia, J.H., Metallurg. Analysis, 2008, vol. 28, p. 14.
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Zhang, X., Han, J.J., Huang, M. et al. Synthesis, crystal structures and antibacterial activities of schiff base ligand and its cobalt(II) complex. Russ J Coord Chem 38, 560–566 (2012). https://doi.org/10.1134/S1070328412080106
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070328412080106