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Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents

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Abstract

Objective: Synthesis of some new some new morpholine linked indole-1,2,3-triazole hybrids and evaluation of their anti-cancer activity. Methods: Cu (I) catalyzed azide-alkyne cycloaddition. MTT assay was used in anticancer activity. Autodock tools were used foe docking studies. Results and Discussion: All the sixteen compounds were screened against A549 (lung), MCF-7 (breast), and HeLa (cervical) and compared with nocodazole. In addition to this tubulin polymerization inhibition assay and docking studies were performed on some active compounds. Conclusions: Synthesized some new 1,2,3-triazole hybrids and screened them for anticancer activity, tubulin polymerization inhibition, and binding interaction with tubulin. Some of the compounds were found active.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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This work was supported by regular institutional funding, and no additional grants were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Satavahana University, Karimnagar, 505002, Telangana, India

    Prasad Pinnoju, Sadanandam Kudikala, Manasa Scandakashi, Madavi Ramesh & Sarasija Madderla

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  1. Prasad Pinnoju
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  2. Sadanandam Kudikala
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  3. Manasa Scandakashi
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  4. Madavi Ramesh
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  5. Sarasija Madderla
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Contributions

The author PP and SK—involved in the synthesis and characterization of the compounds; the author MS—involved in studying the anticancer activity of the compounds; the author MR—involved in docking studies and tubulin polymerization inhibition assay; the author SM—involved in designing the scheme and writing the manuscript

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Correspondence to Sarasija Madderla.

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Pinnoju, P., Kudikala, S., Scandakashi, M. et al. Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents. Russ J Bioorg Chem 50, 293–303 (2024). https://doi.org/10.1134/S1068162024020018

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