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Preparation of 89Zr Solutions for Radiopharmaceuticals Synthesis

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Radiochemistry Aims and scope

Abstract

Zirconium-89 is a promising radionuclide for nuclear medicine and has optimal nuclear-physical parameters for study of processes with slow kinetic. The increasing popularity of targeted imaging has led to a concomitant development of 89Zr radiopharmaceutical chemistry. At present, a tremendous amount of scientific work has been carried out in all fields: from production of 89Zr at accelerators to clinical studies of different radiopharmaceuticals. The review contains a description and comparison of various methods for preparation, extraction, and purification of 89Zr, and discusses the most common chemical forms used in the synthesis of the complexes.

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  1. Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, 123182, Moscow, Russia

    V. B. Bubenshchikov, A. A. Larenkov & G. E. Kodina

  2. Moscow State University, 119991, Moscow, Russia

    A. A. Larenkov

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  1. V. B. Bubenshchikov
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Translated from Radiokhimiya, No. 3, pp. 281–295, April, 2021 https://doi.org/10.31857/S0033831121030114

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Bubenshchikov, V.B., Larenkov, A.A. & Kodina, G.E. Preparation of 89Zr Solutions for Radiopharmaceuticals Synthesis. Radiochemistry 63, 369–383 (2021). https://doi.org/10.1134/S1066362221030152

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