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Production and radiochemical separation of a potential immuno-PET imaging agent 89Zr from proton irradiated natY target

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Abstract

Zirconium-89 (89Zr) is an interesting immuno-PET imaging agent due to its favorable physical characteristics of 78.4 h half-life and a relatively low positron energy of 0.9 MeV. Radiochemical separation of 89Zr from irradiated yttrium target matrix has been achieved by different separation methodologies like anion-exchange chromatography, cation-exchange chromatography and size exclusion chromatography (Sephadex G-25 resin). A novel and simple method based on size exclusion chromatography (Sephadex G-25) for radiochemical separation of 89Zr with no harmful substances has been explored. The experimental yield of 89Zr from natural yttrium target was found to be 27 MBq/μAh using 12 MeV proton. The radiochemical separation yield, radionuclidic purity and chemical purity of 89Zr using an anion exchanger, Dowex-1 resin/2 M HCl column system and Sephadex G-25 resin column was found to be high enough.

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Acknowledgements

The authors thank Shri G. Ganesh, Chief Executive, BRIT for his supports. The authors also thank Dr. Sharmila Banerjee, Senior General Manager, BRIT for her encouragement and support in the work. The authors are grateful to Shri Amitava Roy, Acting Director, VECC for his support and cyclotron operators at VECC for target irradiations.

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Authors and Affiliations

  1. Radiopharmaceuticals Laboratory, Regional Centre, Board of Radiation and Isotope Technology(BRIT), Variable Energy Cyclotron Centre (VECC), 1/AF, Bidhan Nagar, Kolkata, 700064, India

    Sujata Saha Das, Sankha Chattopadhyay, Luna Barua, Md. Nayer Alam,  Madhusmita & Umesh Kumar

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  1. Sujata Saha Das
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  2. Sankha Chattopadhyay
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  3. Luna Barua
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  4. Md. Nayer Alam
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Correspondence to Sankha Chattopadhyay.

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Das, S.S., Chattopadhyay, S., Barua, L. et al. Production and radiochemical separation of a potential immuno-PET imaging agent 89Zr from proton irradiated natY target. J Radioanal Nucl Chem 313, 641–645 (2017). https://doi.org/10.1007/s10967-017-5316-9

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  • DOI: https://doi.org/10.1007/s10967-017-5316-9

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