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Radiochemical and biological characterization of 99mTc-oxiracetam as a model for brain imaging

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Radiochemistry Aims and scope

Abstract

99mTc-oxiracetam was prepared. It can be used as a radiotracer for brain imaging. Under the optimum conditions (0.5 mg of oxiracetam, 50 μg of SnCl2·2H2O, pH 7, room temperature, 30 min), the radio-chemical yield determined by chromatographic methods reached 96%. Biodistribution studies with mice showed that the brain uptake of the complex was 5.1% injected dose per gram (% ID/g) at 5 min post injection. In this parameter, the complex surpasses the commercially available 99mTc-ECD (4.7% ID/g) and 99mTc-HMPAO (2.25% ID/g).

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad & O. A. El-Kawy

  2. Biological Application Department, Nuclear Research Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    E. A. Marzook

Authors
  1. M. H. Sanad
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  2. E. A. Marzook
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  3. O. A. El-Kawy
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Corresponding author

Correspondence to M. H. Sanad.

Additional information

Published in Russian in Radiokhimiya, 2017, Vol. 59, No. 6, pp. 549–553.

The text was submitted by the authors in English.

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Sanad, M.H., Marzook, E.A. & El-Kawy, O.A. Radiochemical and biological characterization of 99mTc-oxiracetam as a model for brain imaging. Radiochemistry 59, 624–629 (2017). https://doi.org/10.1134/S1066362217060011X

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  • DOI: https://doi.org/10.1134/S1066362217060011X

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