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Radiosynthesis and Biological Evaluation of 99mTc Nitrido-Levetiracetam as a Brain Imaging Agent

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Radiochemistry Aims and scope

Abstract

99mTc nitrido-Levetiracetam was prepared using the 99mTc nitrido core for labeling. The reaction conditions were optimized to get the highest radiochemical purity (98%): substrate amount 2 mg, Sn(II) (reducing agent) amount 50 µg, pH 7, 30 min, ambient temperature. The biodistribution studies revealed high brain uptake of 99mTc nitride-Levetiracetam, reaching a maximum of 9% ID/g at 30 min post injection (p.i.). The complex deserves further analysis as a candidate brain imaging agent.

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ACKNOWLEDGMENTS

I would like to extend my sincere thanks and gratitude to everyone who gave me even a small contribution to accomplish this fruitful work, starting with the authors participating in the this work, as well as my professors, colleagues and students. I would also like to thank my family who created the right conditions for me to do this work, my father, mother, wives, brothers as well as all my children: Mohammed, Menna, Abd-Allah, Hamdi, Mostafa and Maryam Sanad. In addition, this work was supported by STDF–National Research Centre under project number 41535.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, PB13759, Cairo, Egypt

    M. H. Sanad & F. A. Marzook

  2. Department of Physics and Engineering Mathematics, Faculty of Engineering, Ain Shams University, 11566, Cairo, Egypt

    M. H. Sanad

  3. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China

    S. F. A. Rizvi

  4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 12578, Giza, Egypt

    A. B. Farag

  5. Food Toxicology and Contaminants Department, National Research Centre, Dokki, PB12622, Cairo, Egypt

    A. S. M. Fouzy & Sabry A. Bassem

  6. Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, 713206, West Bengal, India

    Sudip Kumar Mandal

  7. Guru Nanak Institutions Technical Campus, Ibrahimpatnam, 501506, Hyderabad, India

    Soumya Stuti Patnaik

  8. Laboratory of Organometallics, Catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 430070, Wuhan, China

    Francis Verpoort 

  9. Ghent University, Global Campus Songdo, 119 Songdomunhwa-Ro, Yeonsu-Gu, 21985, Incheon, South Korea

    Francis Verpoort 

  10. Radiation Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, PB13759, Cairo, Egypt

    H. M. Eyssa

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  1. M. H. Sanad
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  2. H. M. Eyssa
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  3. F. A. Marzook
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  4. A. B. Farag
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  8. A. S. M. Fouzy
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Correspondence to M. H. Sanad or S. F. A. Rizvi.

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Sanad, M.H., Eyssa, H.M., Marzook, F.A. et al. Radiosynthesis and Biological Evaluation of 99mTc Nitrido-Levetiracetam as a Brain Imaging Agent. Radiochemistry 63, 635–641 (2021). https://doi.org/10.1134/S106636222105012X

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