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Synthesis of [18F]-L-DOPA radiopharmaceutical on a modified GE TracerLAB Fx F-E platform

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Radiochemistry Aims and scope

Abstract

A procedure was developed for preparing [18F]-5-hydroxy-2-fluoro-L-thyrosine ([18F]-fluoro-L-dihydroxyphenylalanine, [18F]-L-DOPA) radiopharmaceutical on modified commercially available GE Tracer-LAB Fx F-E platform. This modification can be used for preparing both [18F]-L-DOPA and any other radiopharmaceuticals by electrophilic radiofluorination. The procedure allows preparation of the product meeting all the requirements of European Pharmacopoeia (8th ed.) for clinical use with the decay-corrected radiochemical yield of 20 ± 3% (n = 3).

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Authors and Affiliations

  1. Almazov Northwestern Federal Medical Research Center, Ministry of Public Health of the Russian Federation, ul. Akkuratova 2, St. Petersburg, 197341, Russia

    D. O. Antuganov, M. P. Zykov, D. V. Ryzhkova, T. A. Zykova, A. A. Vinal’ev, Yu. O. Antuganova & O. P. Samburov

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  1. D. O. Antuganov
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  2. M. P. Zykov
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  3. D. V. Ryzhkova
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  4. T. A. Zykova
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  5. A. A. Vinal’ev
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  6. Yu. O. Antuganova
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  7. O. P. Samburov
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Correspondence to D. O. Antuganov.

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Original Russian Text © D.O. Antuganov, M.P. Zykov, D.V. Ryzhkova, T.A. Zykova, A.A. Vinal’ev, Yu.O. Antuganova, O.P. Samburov, 2016, published in Radiokhimiya, 2016, Vol. 58, No. 6, pp. 556–560.

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Antuganov, D.O., Zykov, M.P., Ryzhkova, D.V. et al. Synthesis of [18F]-L-DOPA radiopharmaceutical on a modified GE TracerLAB Fx F-E platform. Radiochemistry 58, 649–653 (2016). https://doi.org/10.1134/S1066362216060138

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  • DOI: https://doi.org/10.1134/S1066362216060138

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