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Methods for the synthesis of fluorine-18-labeled aromatic amino acids, radiotracers for positron emission tomography (PET)

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Abstract

Potential of electrophilic and nucleophilic methods of radiofluorination in the synthesis of fluorine-18-labeled fluorinated amino acid analogs, radiotracers for positron emission tomography (PET), is considered. The synthesis of 6-L-[18F]FDOPA ((S)-2-amino-3-(6-[18F]fluoro-3,4-dihydroxyphenyl)propionic acid) was used as an example to discuss new elaborations in this field directed on both the improvement of already existing methods and the development of fundamentally new approaches to the introduction of a fluorine-18 label into the nonactivated aromatic ring of amino acids using nucleophilic methods.

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Authors and Affiliations

  1. N. P. Bekhtereva Institute of Human Brain, Russian Academy of Sciences, 9 ul. Akad. Pavlova, 197376, St.-Petersburg, Russian Federation

    V. V. Orlovskaya, O. S. Fedorova & R. N. Krasikova

  2. Department of Chemistry, St.-Petersburg State University, 7-9 Universitetskaya nab., 199034, St.-Petersburg, Russian Federation

    R. N. Krasikova

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  1. V. V. Orlovskaya
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  2. O. S. Fedorova
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  3. R. N. Krasikova
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1518–1535, July, 2015.

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Orlovskaya, V.V., Fedorova, O.S. & Krasikova, R.N. Methods for the synthesis of fluorine-18-labeled aromatic amino acids, radiotracers for positron emission tomography (PET). Russ Chem Bull 64, 1518–1535 (2015). https://doi.org/10.1007/s11172-015-1037-9

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