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Preparation and biodistribution of radioiodinated analgin as a possible inflammatory imaging agent

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Radiochemistry Aims and scope

Abstract

Direct radioiodination of analgin with 125I was carried out using chloramine-T as an oxidizing agent. The labeling conditions were optimized. When performed with 50 μg of analgin and 10 μg of chloramine-T at pH 9 for 15 min at room temperature, the reaction gives 97.5 ± 1.2% radiochemical yield of 125I-analgin. The radiochemical yield of the final product was determined by electrophoresis and HPLC. Biodistribution studies were carried out in normal Albino Swiss mice and in those with septic and aseptic inflammations at different time intervals after administration of radioiodinated analgin. It was found that radioiodinated analgin differentiates between septic and aseptic inflammations and can be used to detect inflammation.

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References

  1. Britton, K.E., Vinjamuri, S., and Hall, A.V., Eur. J. Nucl. Med., 1997, vol. 24, pp. 553–555.

    CAS  Google Scholar 

  2. Rennen, H.J.M., Boerman, O.C., Oyen, W.J.G., and Corstens, F.H.M., Med. Chem. Rev., 2004, vol. 1, pp. 27–30.

    CAS  Google Scholar 

  3. Das, S.S., Hall, A.V., Wareham, D.D.W., and Britton, K.E., Brazil Arch. Biol. Technol., 2002, vol. 45, p. 25.

    Article  CAS  Google Scholar 

  4. Lupetti, A., Welling, M.M., Paulwels, E.K.J., and Nibbering, P.H., Lancet Infect. Diseases, 2003, vol. 3, pp. 223–226.

    Article  CAS  Google Scholar 

  5. Seabold, J.E., Palestro, C.J., and Brown, M.L., J. Nucl. Med., 1997, vol. 38, p. 994.

    CAS  Google Scholar 

  6. Staab, E.V. and McCartney, H., Semin. Nucl. Med., 1978, vol. 8, p. 219.

    Article  CAS  Google Scholar 

  7. Seabold, J.E., Forstrom, L.A., and Schauwecher, D.S., J. Nucl. Med., 1997, vol. 38, p. 997.

    CAS  Google Scholar 

  8. Schrijver, M.D., Streule, K., and Senekowitsch, R., Nucl. Med. Commun., 1987, vol. 8, p. 895.

    Article  Google Scholar 

  9. Buscombe, J.R., Miller, R.F., and Lui, D., Nucl. Med. Commun., 1991, vol. 12, p. 583.

    Article  CAS  Google Scholar 

  10. McAfee, J.G., Gagne, G., and Subramanian, G., J. Nucl. Med., 1991, vol. 32, p. 2126.

    CAS  Google Scholar 

  11. Akhtar, M.S., Qaisar, A., and Irfanullah, J., J. Nucl. Med., 2005, vol. 46, p. 567.

    CAS  Google Scholar 

  12. Akhtar, M.S., Iqbal, J., and Khan, M.A., J. Nucl. Med., 2004, vol. 45, p. 849.

    CAS  Google Scholar 

  13. Vanderlaken, C.J., Boerman, O.C., Oyen, J.G., et al., Eur. J. Nucl. Med., 1998, vol. 25, p. 535.

    Article  CAS  Google Scholar 

  14. El-Shaboury, G. and El-Tawoosy, M., J. Radioanal. Nucl. Chem., 2002, vol. 252, no. 1, p. 109.

    Article  CAS  Google Scholar 

  15. El-Shaboury, G., Farah, K., and El-Tawoosy, M., J. Radioanal. Nucl. Chem., 2001, vol. 249, no. 3, p. 535.

    Article  CAS  Google Scholar 

  16. El-Tawoosy, M. and Ibrahim, I.T., Radiochemistry, 2012, vol. 54, no. 4, p. 401.

    Article  CAS  Google Scholar 

  17. Shafik, H.M., J. Radioanal. Nucl. Chem., 2009, vol. 281, no. 3, p. 639.

    Article  CAS  Google Scholar 

  18. Sallam, Kh.M. and Mehany, N.L., J. Radioanal. Nucl. Chem., 2009, vol. 281, no. 3, p. 329.

    Article  CAS  Google Scholar 

  19. Amin, A.M., Soliman, S.E., Killa, H.M., and El-Aziz, H.A., J. Radioanal. Nucl. Chem., 2010, vol. 283, no. 2, p. 273.

    Article  CAS  Google Scholar 

  20. El-Ghany, E.A., Farouk, N., and El-Kolaly, M.T., J. Radioanal. Nucl. Chem., 2000, vol. 245, no. 2, p. 243.

    Article  CAS  Google Scholar 

  21. Slabert, J.P., Langerhoven, J.H., and Smit, B.S., J. Radioanal. Nucl. Chem., 1999, vol. 240, no. 2, p. 505.

    Article  Google Scholar 

  22. Fraker, P.J. and Speck, J.C., J. Biochem. Biophys. Res. Commun., 1978, vol. 80, p. 849.

    Article  CAS  Google Scholar 

  23. Danforth, E. and Himms-Hagen, J., Eur. J. Endocrinol., 1997, vol. 136, p. 362.

    Article  CAS  Google Scholar 

  24. Pinguet, F., Culine, S., Bressolle, F., et al., Clin. Cancer Res., 2000, vol. 6, p. 57.

    CAS  Google Scholar 

  25. Laken, V., Boerman, C.J., Oyen, O.C., et al., J. Nucl. Med., 2000, vol. 41, p. 463.

    Google Scholar 

  26. Oyen, W.J.G., Boerman, O.C., and Corstens, F.H.M., J. Microbiol. Meth., 2001, vol. 47, p. 151.

    Article  CAS  Google Scholar 

  27. Asikoglu, M., Yurt, F., Cagliyan, O., et al., Appl. Radiat. Isot., 2000, vol. 53, p. 411.

    Article  CAS  Google Scholar 

  28. Korde, A., Venkatesh, M., and Sarma, H.D., in Int. Symp. on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy, Lisbon (Portugal), March 30–April 3, 1998, IAEA, SM-355/13.

    Google Scholar 

  29. Knust, E.J., Dutschka, K., and Machulla, H.J., J. Radioanal. Nucl. Chem., Lett., 1990, vol. 144, p. 107.

    Article  CAS  Google Scholar 

  30. Cynthia, B.F., Roger, K.D., Kaumann, A.J., et al., J. Mol. Pharmacol., 1979, vol. 12, p. 328.

    Google Scholar 

  31. Saccavini, J.C. and Bruneau, C., IAEA CN-4519, 1984, p. 153.

    Google Scholar 

  32. Rayudu, G.V.S., Radiotracers for Medical Application, CRS Ser.: Radiotracers in Biology and Medicine, 1983, p. 11.

    Google Scholar 

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. El-Tawoosy

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  1. M. El-Tawoosy
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Correspondence to M. El-Tawoosy.

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Published in Russian in Radiokhimiya, 2014, Vol. 56, No. 4, pp. 364–367.

The text was submitted by the author in English.

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El-Tawoosy, M. Preparation and biodistribution of radioiodinated analgin as a possible inflammatory imaging agent. Radiochemistry 56, 428–432 (2014). https://doi.org/10.1134/S1066362214040122

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  • DOI: https://doi.org/10.1134/S1066362214040122

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