Skip to main content
SpringerLink
Log in

Radiodiagnosis of peptic ulcer with technetium-99m-pantoprazole

  • Published:
Radiochemistry Aims and scope

Abstract

Pantoprazole, antiulcer drug, was labeled with 99mTc to obtain an agent for ulcer imaging. The radiochemical yield of 99mTc-Pantoprazole reaches approximately 96.5%. The optimum conditions are as follows: pH 10, 75 μg of tin chloride, 30 min, and 2 mg of the substrate. 99mTc-Pantoprazole was stable for 3 h. Intravenous biodistribution studies of 99mTc-Pantoprazole revealed high concentration in the stomach ulcer, reaching about 27.2% of the total injected dose at 30 min post injection. This concentration of 99mTc-Pantoprazole in stomach ulcer makes this agent promising for stomach ulcer imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Simon, W.A., Keeling, D.J., Laing, S.M., et al., Biochem Pharmacol., 1990, vol. 39, p. 1799.

    Article  CAS  Google Scholar 

  2. Kohl, B., Sturm, E., Senn-Bilfinger, J., et al., J. Med. Chem., 1992, vol. 35, p. 1049.

    Article  CAS  Google Scholar 

  3. Jungnickel, P.W., Clin Ther., 2000, vol. 22, p. 1268.

    Article  CAS  Google Scholar 

  4. Cheer, S.M., Prakash, A., Faulds, D., and Lamb, H.M., Drugs, 2003, vol. 63, p. 101.

    Article  CAS  Google Scholar 

  5. Huber, R., Hartmann, M., Bliesath, H., et al., Int. J. Clin. Pharmacol. Ther., 1996, vol. 16, p. 34.

    Google Scholar 

  6. Balderas-Acata J.I., Ríos-Rogríguez Bueno, E.P., del Castillo-García, S., et al., J. Bioequiv. Availab., 2011, vol. 3, p. 77.

    CAS  Google Scholar 

  7. Campos, D.R., Klein, S., Zoller, T., et al., Arzneimittelforschung, 2010, vol. 60, p. 42.

    Google Scholar 

  8. Snowden, F.M., Immunol. Rev., 2008, vol. 1, p. 9.

    Article  Google Scholar 

  9. Loughlin, M.F., Ala’Aldeen, D.A., and Jenks, P.J., J. Antimicrob. Chemother., 2003, vol. 2, p. 367.

    Article  Google Scholar 

  10. Bebb, J.R., Bailey-Flitter, N., Ala’Aldeen, D., and Atherton, J.C., J. Antimicrob. Chemother., 2003, vol. 3, p. 522.

    Article  Google Scholar 

  11. Traversa, G., Walker, A.M., Ippolito, F.M., et al., Epidemiology, 1995, vol. 1, p. 49.

    Article  Google Scholar 

  12. El-Shahawi, M.S., El-Shaboury, G., Aly, M.A.M., and El-Tawoosy, M., Anal. Sci., 2003, vol. 9, p. 1331.

    Article  Google Scholar 

  13. Boyd, R.E., Nucl. Spectrum, 1986, vol. 2, p. 18.

    Google Scholar 

  14. Robbins, P.J., Chromatography of Technetium-99m Radiopharmaceuticals, a Practical Guide, New York: Soc. of Nuclear Medicine, 1984.

    Google Scholar 

  15. Motaleb, M.A., Synthesis and Evaluation of Some 99mTc Complexes Applied in Nuclear Medicine, PhD Thesis, Cairo (Egypt), Faculty of Science, Ain-Shams Univ., 2001.

    Google Scholar 

  16. Guarna, A., Menchi, G., Berti, G., et al., Bioorg. Med. Chem., 2001, vol. 9, p. 3197.

    Article  CAS  Google Scholar 

  17. Liu, K.-Y., Zhu, Y., Chen, G.-B., et al., Zhongguo Zhongyao Zazhi, 2007, vol. 21, p. 2286.

    Google Scholar 

  18. Johannsen, B. and Spies, H., Chemistry and Radiopharmacology of Technetium Complexes, Workshop on Generator and Cyclotron Produced Radiopharmaceuticals, Riyad (Saudi Arabia), October 1991.

    Google Scholar 

  19. Marshall, B.J., Lancet, 1983, vol. 8, p. 1273.

    Google Scholar 

  20. Abd El-Ghany, E.A., Studies on the Preparation of Lyophilized Radiopharmaceutical Kits and Their Evaluation, M.Sci. Thesis, Cairo (Egypt): Faculty of Pharmacy, Cairo Univ., 1998.

    Google Scholar 

  21. Svoboda, K., Lezama, J., Tendilla, J., et al., J. Radioanal. Nucl. Chem. Lett., 1985, vol. 4, p. 405.

    Google Scholar 

  22. Yang, Y.X., Lewis, J.D., Epstein, S., and Metz, D.C., JAMA, 2006, vol. 296, p. 2947.

    Article  CAS  Google Scholar 

  23. Sanad, M.H., Synthesis and Labeling of Some Organic Compounds with One of the Most Radioactive Isotopes, PhD Thesis, Cairo (Egypt): Chemistry Department, Faculty of Science, Ain-Shams Univ., 2007.

    Google Scholar 

  24. Thjodleiffson, B., Beker, J.A., Dekkers, C., et al., Digest Dis. Sci., 2000, vol. 45, p. 845.

    Article  Google Scholar 

  25. Abdel-Motalab, M.A. and Sanad, M.H., Arab J. Nucl. Sci. Appl., 2012, vol. 45, p. 71.

    Google Scholar 

  26. Proulx, A., Ballinger, J.R., and Gulenchyn, K.Y., Int. J. Appl. Radiat. Isot., 1989, vol. 1, p. 95.

    Google Scholar 

  27. Ibrahim, T., El-Tawoosy, M., and Talaat, H.M., Network Pharm., 2011, vol. 5, p. 42.

    Google Scholar 

  28. Ibrahim, I.T., J. Radioanal. Nucl. Chem., 2009, vol. 281, p. 669.

    Article  CAS  Google Scholar 

  29. Ridone, S., Arginelli, D., Inglese, E., et al., J. Radioanal. Nucl. Chem., 2009, vol. 282, p. 287.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad & I. T. Ibrahim

Authors
  1. M. H. Sanad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. T. Ibrahim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. H. Sanad.

Additional information

Published in Russian in Radiokhimiya, 2013, Vol. 55, No. 3, pp. 280–283.

The text was submitted by the authors in English.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sanad, M.H., Ibrahim, I.T. Radiodiagnosis of peptic ulcer with technetium-99m-pantoprazole. Radiochemistry 55, 341–345 (2013). https://doi.org/10.1134/S106636221303017X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S106636221303017X

Keywords

Search

Navigation