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Evaluation of in vitro and in vivo stability of the radiopharmaceutical [153Sm]Sm-EDTMP for biokinetics studies in bone metastases pain palliation care

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Abstract

The radiopharmaceutical [153Sm]Sm-EDTMP is administered for painful bone metastases with the standard dosage of 37 MBq/kg, without evaluation of patient individual characteristics. For a better dose estimate in vivo stability should be considered, because labelled and unlabelled samarium do not have the same metabolic pathway. We evaluated radiopharmaceutical in vitro stability, measuring the activity by beta and gamma spectrometry. Subsequently we verified in vivo stability on serial blood and urine samples. The percentage of the unlabelled radiopharmaceutical is high and, on the basis of radiochemical data as well as blood clearance and urine excretion, we calculated the main parameters for a preliminary biokinetic model.

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Authors and Affiliations

  1. ENEA-Italian National Agency for New Technologies, Energy and the Environment Research Centre of Saluggia, strada per Crescentino 41, 13040, Saluggia, VC, Italy

    S. Ridone, D. Arginelli & M. Montalto

  2. Department of Biotechnologies, Agro-Industry and Health Protection, Radiation Protection Institute, strada per Crescentino 41, 13040, Saluggia, VC, Italy

    S. Ridone, D. Arginelli & M. Montalto

  3. Department of Nuclear Medicine, Hospital “Maggiore della Carità” of Novara, corso Mazzini 18, 28100, Novara, Italy

    E. Inglese, A. Lucca, M. Rudoni & S. Vallegiani

  4. Department of Medical Physics, Hospital “Maggiore della Carità” of Novara, corso Mazzini 18, 28100, Novara, Italy

    R. Matheoud & C. Secco

  5. Department of Experimental Physics, University of Turin, via Pietro Giuria 1, 10125, Turin, Italy

    A. Miranti, C. Peroni & L. Vigna

Authors
  1. S. Ridone
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  2. D. Arginelli
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  3. E. Inglese
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  4. A. Lucca
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  5. R. Matheoud
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  6. A. Miranti
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  7. M. Montalto
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  8. C. Peroni
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  9. M. Rudoni
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  10. C. Secco
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  11. S. Vallegiani
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  12. L. Vigna
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Corresponding author

Correspondence to S. Ridone.

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Ridone, S., Arginelli, D., Inglese, E. et al. Evaluation of in vitro and in vivo stability of the radiopharmaceutical [153Sm]Sm-EDTMP for biokinetics studies in bone metastases pain palliation care. J Radioanal Nucl Chem 282, 287–291 (2009). https://doi.org/10.1007/s10967-009-0277-2

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  • DOI: https://doi.org/10.1007/s10967-009-0277-2

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