Abstract
The possibility of using fibrous filled sorbents for efficient purification and conditioning of the eluate of a 68Ge/68Ga generator was demonstrated. The eluate thus prepared was used to label octreo-tide with 68Ga with the aim to obtain a radiopharmaceutical for imaging neuroendocrine and other tumors by positron emission tomography. A pilot installation for prompt and reliable conditioning of the eluate of a 68Ge/68Ga generator was designed and fabricated. The resulting eluate was used to label the modified peptide on the nanomolar level in a high yield.
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Dmitriev, S.N., Zaitseva, N.G., and Ochkin, A.V., Radionuklidy dlya yadernoi miditsiny i ekologii. Yadernye dannye, melody polucheniya, primenenie v yadernoi meditsine i monitoringe okruzhayushchei sredy: Uchebnoe posobie (Radionuclides for Nuclear Medicine and Ecology. Nuclear Properties, Preparation Procedures, Application to Nuclear Medicine and Environmental Monitoring: Textbook), Dubna: Ob”edinennyi Inst. Yadernykh Issledovanii, 2001, p. 12.
Breeman, A.P., Jong, M. de, Blois, E. de, et al., Eur. J. Nucl. Med. Mol. Imag., 2005, vol. 32, no. 4, pp. 478–485.
Ambrosini, V., Tomassetti, P., Campana, D., et al., Eur. J. Nucl. Med. Mol. Imag., 2007, vol. 34, no. 10, suppl. 2, p. SI92.
Singh, A., Hart, J.L., Knap, T., et al., Eur. J. Nucl. Med. Mol. Imag., 2007, vol. 34, no. 10, suppl. 2, p. S192.
Aloj, L., Caraco, C, Aurilio, M., et al., Eur. J. Nucl. Med. Mol. Imag., 2007, vol. 34, no. 10, suppl. 2, p. S192.
Buchmann, I., Engelbrecht, S., Yenze, M., et al., Eur. J. Nucl. Med. Mol. Imag., 2007, vol. 34, no. 10, suppl. 2, p. SI92.
Malinin, A.B., Kozlova, M.D., Sevast’yanova, S.A., et al., Proc. Targetry’91, Villigen (Switzerland): Paul Scherrer Inst., 1991, p. 250.
Khimiya i tekhnologiya redkikh i rasseyanykh elementov: Uchebnoe posobie dlya vuzov (Chemistry and Technology of Rare and Dissipated Elements: Textbook for Higher Schools), Bol’shakov, K.A., Ed., Moscow: Vysshaya Shkola, 1976, part 1.
Meyer, G.J., Macke, H., Schuhmacher, J., et al., Eur. J. Nucl. Med. Mol. Imag., 2004, vol. 31, no. 8, pp. 1097–1104.
Myasoedova, G.V., Abstracts of Papers, Chetvertaya Rossiiskaya konferentsiya po radiokhimii “Radiokhimiya 2003” (Fourth Russian Conf. on Radiochemistry “Radiochemistry 2003”), Ozersk, 2003, p. 240.
Kodina, G.E., Kozlova, M.D., Malinin, A.B., et al., RF Patent 2126 271, Priority of February 20, 1999.
Razbash, A.A., Sevastianov, Yu.G., Tolstouhov, Yu.V., et al., Proc. Seventh Workshop on Targetry and Target Chemistry, Heidelberg (Germany), June 8–11, 1997, pp. 48–50.
68Ge/68Ga Generator. Radioisotopic Production, Booklet of Tsiklotron Private Company, Obninsk, 2003.
Marchol, M., Ion Exchangers in Analytical Chemistry: Their Properties and Use in Inorganic Chemistry, Prague: Academia, 1982.
Breeman, W.A.P., Jong, M. de, Blois, E. de, et al., in 12th European Symp. on Radiopharmacy and Radio-pharmaceuticals: Presentation and Book of Abstracts, Sopot (Poland), September 9–12, 2004, p. 29.
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Original Russian Text © V.G. Andronov, A.B. Bruskin, A.S. Sevast’yanova, G.E. Kodina, A.V. Ochkin, G.V. Myasoedova, 2008, published in Radiokhimiya, 2008, Vol. 50, No. 5, pp. 464–468.
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Andronov, V.G., Bruskin, A.B., Sevast’yanova, A.S. et al. Sorption conditioning of eluate of 68Ge/68Ga generator for medical purposes. Radiochemistry 50, 535–540 (2008). https://doi.org/10.1134/S1066362208050172
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DOI: https://doi.org/10.1134/S1066362208050172