Abstract
The present work adds to the continuing efforts of designing a natural bone like structure. In these studies the hydroxyapatite (HA) impregnated polymeric composites of polyacrylamide (PAm) and poly-(vinyl alcohol) (PVA) have been synthesized by free radical polymerization for the purpose of studying their blood compatibility, water sorption behavior mechanical properties, and porosity. The prepared PAm-PVA-HA composites were characterized using techniques like fourier transform spectroscopy, X-ray diffraction studies, thermogravimetric analysis and scanning electron microscopy. The composites were also evaluated for mechanical properties like compressive strength and modulus.
Similar content being viewed by others
References
C. X. F. Lam, X. M. Mo, S. H. Teoh, and D. W. Hutmacher, Mater. Sci. Eng. C 20, 49 (2002).
W. Y. Yeong, C.K. Chua, K.F. Leong, and M. Chandrasekaran, Trends Biotechnol. 22, 643 (2004).
L. Moroni, J. R. de Wijn, and C.A. Blitterswijk, Biomaterials 27, 974 (2006).
R. Langer and J. P. Vacanti, Tissue engineering Science 260, 920 (1993).
A. J. Putnam and D. J. Mooney, Nat. Med. 2, 824 (1996).
M. C. Wake, C. W. Patrick, and A. G. Mikos, Pore Cell Transplant 3, 339 (1994).
S. Higashi, T. Yamamuro, T. Nakamura, Y. Ikada, S.H. Hyon, and K. Jamshidi, Biomaterials 7, 183 (1986).
M. Ito, Biomaterials 12, 41 (1991).
J. Song, E. Saiz, and C. R. Bertozzi, J. Am. Chem. Soc. 125, 1236 (2003).
Z. A. C. Schnepp, R. G. Mc Quire, and S. Mann, Adv. Mater. 18, 1869 (2006).
C. R. Nuttelman, D. S. W. Benoit, M. C. Tripodi, and K. S. Anseth, Biomaterials 27, 1377 (2006).
M. Huang, J. Q. Feng, J. X. Wang, X. D. Zhang, Y. B. Li, and Y. G. Yan, J. Mater. Sci. Mater. Med. 15, 655 (2003).
G. R. Mahadaviniya and A. Pourjavadi, Polym. Adv. Technol. 15, 173 (2004).
P. Bera and S. K. Saha, Polymer 39, 1461 (1998).
F. Ilmain, T. Tanaka, and E. Kokufuta, Nature 349, 400 (1991).
M. Takeda, T. Norisuye, and M. Shibayama, Macromolecules 33, 2909 (2000).
S. Takata, T. Norisuye, and M. Shibayama, Macromolecules 32, 3989 (1999).
A. K. Bajpai and M. Rajpoot, J. Appl. Polym. Sci. 81, 1238 (2001).
T. Ishikawa, M. Wakamura, and S. Kondo, Am. Chem. Soc. 5, 140 (1989) (reprinted from Langmuir).
A. K. Bajpai and R. Sainy, J. Mater. Sci. Mater. Med. 17, 49 (2006).
P. Spulveda, F. S. Ortega, M. D. M. Innocentini, V. C. Pandolfelli, and J. A. M. Ceram. Soc. 83, 3021 (2000).
Y. Zhang and M. Zhang, J. Biomed. Mater. Res. 55, 304 (2001).
A. K. Bajpai and R. Sainy, Polym. Int. 54, 796 (2005).
R. Saini and A. K. Bajpai, Polym. Int. 54, 1233 (2005).
A. K. Bajpai and D. D. Mishra, J. Mater. Sci. Mater. Med. 15, 583 (2004).
A. K. Bajpai and S. Kankane, J. Appl. Polym. Sci. 104, 1559 (2007).
Y. Wang, X. Wang, K. Wei, J. Matlet. 61, 1071 (2007).
A. C. Tas, Biomaterials 21, 1429 (2000).
L. Juan-Zhang, J. Matlet. 58, 719 (2004).
K. C. Blakeslee and R. A. Candrate, J. Am. Ceram. Soc. 54, 559 (1971).
A. Pouravadi and R. G. Mahdavinia, Turk. J. Chem. 30, 595 (2006).
R. M. Silverstein, G. L. Bassler, and T. C. Morril, Spectrometric Identification of Organic Compounds (Wiley, New York, 1991).
M. N. Rahaman, Ceramics Processing and Sintering (Marcel Dekker, New York, 1995).
K. Prabhakaran, T.V. Thamaraiselvi, and S. Rajeshwari, Trends Biomater. Artif. Organs. 19, 84 (2006).
Y. Sang, S. Wen, and M. Li, in Mat. Res. Soc. Symp. Proc., Materials Research Society, 2002, p. 724.
R. Murugan, S. Ramkrishna, and K. Panduranga, J. Matlet. 60, 2844 (2006).
G. Zheng, X. Jiu, and Z. Xiang, Biomed. Mater. Eng. 8, 75 (1998).
R. A. Magnussen, F. Guilak, and T. P. Vail, J. Orthop. Res. 23, 576 (2005).
A. C. Tas, Key Engineering Materials 264, 2079 (2004).
M. J. Yaszemski and R. G. Payne, Biomaterials 17, 171 (1996).
A. K. Bajpai and A. Mishra, Polym.Int. 54, 1347 (2005).
A. K. Bajpai, J. Polym. Int. 56, 231 (2007).
M. K. Narbat, M. S. Hashtjin, and M. Pazouki, Engineering Iranian J. Biotechnology 4, 54 (2006).
T. S. Pradeesh, M. C. Sunny, H. K. Varma, Bull. Mater. Sci. 28, 383 (2005).
A. S. Hoffman, Am. Chem. Soc. 199, 3 (1982).
B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, Biomaterials Science: An Introduction to Materials in Medicine (Elsevier Academic Press, Amsterdam, 2004), pp. 332–338.
J. D. Andrade, S. Nagaoka, S. L. Cooper, T. Okano, and S. W. Kim, Trans. Am. Soc. Artif. Intern. Organs. 33, 75 (1987).
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Bundela, H., Bharadwaj, V. Synthesis and characterization of hydroxyapatite-poly-(vinyl alcohol) based nanocomposites for their perspective use as bone substitutes. Polym. Sci. Ser. A 54, 299–309 (2012). https://doi.org/10.1134/S0965545X12040013
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0965545X12040013