Abstract
The relationship between the sensation of lack of air caused by the addition of carbon dioxide to inhaled air and minute pulmonary ventilation was studied in eight healthy male volunteers. Under the conditions of both natural respiration and controlled artificial ventilation of the lungs, ventilation increased in proportion to the increase in the partial pressure of CO2 in the end-tidal exhaled air. The individual differences in the ventilation responses to CO2 under the conditions of controlled ventilation and natural ventilation are regarded as a property of voluntary control.
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Pogodin, M.A. and Donina, Zh.A., On Human Capacity for Controlling Artificial Ventilation of the Lungs, Fiziol. Zh. im. I.M. Sechenova, 1994, vol. 80, no. 5, p. 54.
Pogodin, M.A., Bobrova, E.V., and Granstrem, M.P., Self-Control of Artificial Respiration, Fiziol. Zh. im I.M. Sechenova, 2003, vol. 89, no. 5, p. 572.
Pogodin, M.A., Bobrova, E.V., and Granstrem, M.P., Voluntary and Involuntary Control of Breathing with Imposed Ventilation Parameters, Fiziol Chel., 2004, vol. 30, no. 3, p. 81 [Hum. Physiol. (Engl. Transl.), vol. 30, no. 3, pp. 324–329].
Moxham, J., Respiratory Muscle Fatigue—Aspects of Detection and Treatment, Bull. Eur. Physiopathol. Respir., 1984, vol. 20, p. 437.
Gandevia, S.C., Allen, G.M., Butler, J.E., et al., Human Respiratory Muscles: Sensations, Reflexes and Fatiguability, Clin. Exp. Pharmacol. Physiol., 1998, vol. 25, no. 10, p. 757.
Moosavi, S.H., Topulos, G.P., Hafer, A., et al., Acute Partial Paralysis Alters Perceptions of Air Hunger, Work and Effort at Constant P(CO(2) and V(E), Respir. Physiol., 2000, vol. 122, no. 1, p. 45.
Stark, R.D. and Guz, A., Dispnoea, in SYMPTOMS—A Continuing Monograph Series on Physiology as Applied to Medicine, Conwey, F.J., Ed., Pharmaceuticals Division of ICI, 1997.
Read, D.J.C., A Clinical Method for Assessing the Respiratory Response to Carbon Dioxide, Austral. Ann. Med., 1967, vol. 16, p. 20.
Pogodin, M.A., Granstrem, M.P., and Mikhailov, G.N., A Device for Mechanical Ventilation of the Lungs with the Possibility of a Simultaneous Control by a Subject of the Air Supply Rate and an Inspiratory Volume, Fiziol. Chel., 2005, vol. 31, no. 2, p. 130 [Hum. Physiol. (Engl. Transl.), 2005, vol. 31, no. 2, pp. 233–234].
Safonov, V.A., Minyaev, V.I., and Polunin, I.N., Dykhanie?!? (Respiration?!?), Moscow, 2000.
Guz, A., Brain, Breathing and Breathlessness, Respir. Physiol., 1997, vol. 109, p. 197.
Hugelin, A., Forebrain and Midbrain Influence on Respiration in Handbook of Physiology. Sec. 3. The Respiratory System, Bethesda, Maryland, 1986, vol. 2, part 1, p. 69.
Jenkins, I.H., Jahaushahi, M., Jueptuer, M., et al., Self-Initiated versus Externally Triggered Movements. II. The Effect of Movement Predictability on Regional Cerebral Blood Flow, Brain, 2000, vol. 123, Part 6, p. 1216.
Isae, G., Murphy, K., Guz, A., and Adams, L., Areas of the Brain Concerned with Ventilatory Load Compensation in Awake Man, J. Physiol., 2002, vol. 539, no. 3, p. 935.
Ioffe, M.E., Mekhanizmy dvigatel’nogo obuchnya (Mechanisms of Motor Training), Moscow: Nauka, 1991.
Evans, K.C., Banzett, R.B., Adams, L., et al., BOLD fMRI Identifies Limbic, Paralimbic, and Cerebellar Activation during Air Hunger, J. Neurophysiol., 2002, vol. 88, no. 3, p. 1500.
Frankenshtein, S.I. and Sergeeva, Z.N., Samoregulyatsia dykhaniya v norme i patologii (Normal and Pathological Self-Regulation of Respiration), Moscow, 1966.
Safonov, V.A., Kak dyshim, tak i zhivem (We Live as We Breathe), Moscow, 2004.
Davenport, P.W. and Reep, R.L., Cerebral Cortex and Respiration, in Regulation of Breathing, Dempsy, J. and Pack, A., Eds., New York, 1994, Ch. 6, p. 365.
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Original Russian Text © M.A. Pogodin, M.P. Granstrem, A.I. Dimitrienko, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 4, pp. 77–82.
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Pogodin, M.A., Granstrem, M.P. & Dimitrienko, A.I. Comparison of responses to CO2 under the conditions of natural respiration and controlled artificial pulmonary ventilation. Hum Physiol 32, 440–444 (2006). https://doi.org/10.1134/S0362119706040098
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DOI: https://doi.org/10.1134/S0362119706040098