Skip to main content
SpringerLink
Log in

Mathematical modeling of a chemoreceptor mechanism and the breakpoint of breath holding and experimental evaluation of the model

  • Biophysics of Complex Systems
  • Published:
Biophysics Aims and scope Submit manuscript

Abstract

Using mathematical modeling of respiratory rhythm generation and the breakpoint of breath holding, the dependence of gas-exchange dynamics and the duration of voluntary breath holding on chemoreceptor regulation of the respiratory system was studied. With data from experiments on ten volunteers who had performed their maximum breath holding after maximum inspiration and after maximum expiration, it was shown that experimentally obtained values of the duration of breath holding after expiration were approximately 70% of those predicted by the model. This is an estimation of the contribution of chemoreceptor control to breath holding. The results support the concept of the key role of chemoreceptors at the breakpoint of breath holding.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. J. Parkes, Exp. Physiol. 91, 1 (2006).

    Article  Google Scholar 

  2. I. S. Breslav, Ya. A. Bedrov, and A. M. Shmeleva, Fiziol. Zh. SSSR im. I. M. Sechenova 7, 997 (1976).

    Google Scholar 

  3. Z. L. Topor, M. Pawlicki, and J. E. Remmers, Ann. Biomed. Eng. 32, 153 (2004).

    Article  Google Scholar 

  4. K. Lu, J. W. Clark, Jr., F. H. Ghorbel, et al., Cardiovasc. Eng. 3, 1 (2003).

    Article  Google Scholar 

  5. I. A. Rybak, N. A. Shevtsova, J. F. R. Paton, et al., Resp. Physiol. Neurobiol. 143, 321 (2004).

    Article  Google Scholar 

  6. J. C. Smith, A. P. L. Abdala, H. Koizumi, et al., J. Neurophysiol. 98, 3370 (2007).

    Article  Google Scholar 

  7. A. Ben-Tala and J. C. Smith, J. Theor. Biol. 251, 480 (2008).

    Article  Google Scholar 

  8. Y. I. Molkov, N. A. Shevtsova, C. Park, et al., PLOS ONE 9 (10), e109894 (2014).

    Article  ADS  Google Scholar 

  9. L. Cheng, O. Ivanova, H. Fan, et al., Resp. Physiol. Neurobiol. 174, 4 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    A. O. Goncharov, A. I. Dyachenko, Y. A. Shulagin & E. S. Ermolaev

  2. Bauman Moscow State Technical University, Moscow, 105005, Russia

    A. I. Dyachenko & E. S. Ermolaev

  3. Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow oblast, 141701, Russia

    A. I. Dyachenko

  4. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, 119991, Russia

    A. I. Dyachenko

Authors
  1. A. O. Goncharov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. I. Dyachenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. A. Shulagin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. S. Ermolaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. O. Goncharov.

Additional information

Original Russian Text © A.O. Goncharov, A.I. Dyachenko, Y.A. Shulagin, E.S. Ermolaev, 2017, published in Biofizika, 2017, Vol. 62, No. 4, pp. 794–801.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Goncharov, A.O., Dyachenko, A.I., Shulagin, Y.A. et al. Mathematical modeling of a chemoreceptor mechanism and the breakpoint of breath holding and experimental evaluation of the model. BIOPHYSICS 62, 650–656 (2017). https://doi.org/10.1134/S0006350917040078

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006350917040078

Keywords

Search

Navigation