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Solution State Studies on Some Binary Metal Complexes of Salbutamol

  • PHYSICAL CHEMISTRY OF SOLUTIONS
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Abstract

The transition metal complexes of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with 4-[2-tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol (salbutamol) have been studied in solution state by using the Irving–Rossotti titration method at different temperatures (298.15, 303.15, 308.15 K) and at different ionic strength 0.1, 0.2, 0.3, and 0.4 M (HClO4) in aqueous medium. The protonation constants of salbutamol are calculated by Fortran IV programs using PKAS and BEST, and by point-wise and half-integral method. The metal–ligand stability constants are calculated by using BEST program. The thermodynamic parameters ∆G, ∆H, and ∆S are also calculated. The species distribution diagrams of metal–ligand system were drawn using SPE PLOT program. Results of this study reveal that ML2 type of complexes are more in percentage. Donor sites on optimized Salbutamol molecule were identified with computational study.

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Authors and Affiliations

  1. Department of Chemistry, Hemchandracharya North Gujarat University, 384265, Patan, Gujarat, India

    Sangita Sharma & Ashok Chaudhari

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  1. Sangita Sharma
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  2. Ashok Chaudhari
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Correspondence to Sangita Sharma.

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Sharma, S., Chaudhari, A. Solution State Studies on Some Binary Metal Complexes of Salbutamol. Russ. J. Phys. Chem. 96, 2697–2703 (2022). https://doi.org/10.1134/S0036024422120214

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  • DOI: https://doi.org/10.1134/S0036024422120214

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