Abstract
The transition metal complexes of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with 4-[2-tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol (salbutamol) have been studied in solution state by using the Irving–Rossotti titration method at different temperatures (298.15, 303.15, 308.15 K) and at different ionic strength 0.1, 0.2, 0.3, and 0.4 M (HClO4) in aqueous medium. The protonation constants of salbutamol are calculated by Fortran IV programs using PKAS and BEST, and by point-wise and half-integral method. The metal–ligand stability constants are calculated by using BEST program. The thermodynamic parameters ∆G, ∆H, and ∆S are also calculated. The species distribution diagrams of metal–ligand system were drawn using SPE PLOT program. Results of this study reveal that ML2 type of complexes are more in percentage. Donor sites on optimized Salbutamol molecule were identified with computational study.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS0036024422120214/MediaObjects/11504_2022_4950_Fig1_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS0036024422120214/MediaObjects/11504_2022_4950_Fig2_HTML.png)
Similar content being viewed by others
REFERENCES
Valerie A. Cullum, J. B. Farmer, D. Jack, and G. P. Levy, Brit. J. Pharmacol. 35, 141 (1969).
A. Ullman, J. Hedner, and N. Svedmyr, Am. Rev. Respir. Dis. 142 (571), 5 (1990).
D. W. Cockcroft, C. P. McParland, S. A. Britto, et al., Lancet 342 (8875), 833 (1993).
M. Patel and N. C. Thomson, Expert Opin. Pharmacother. 12, 1133 (2011).
S. Fogli, F. Stefanelli, A. Martelli, et al., Pulmon. Pharmacol. Ther. 26, 693 (2013).
M. Hostrup, A. Kalsen, M. Auchenberg, et al., Scand. J. Med. Sci. Sports 26 (1), 8 (2016).
Ch. X. Zhang and S. J. Lippard, Curr. Opin. Chem. Biol. 7, 481 (2003).
J. Reedijk, Macromol. Symp. 270, 193 (2008).
U. Schatzschneider, Eur. J. Inorg. Chem. 2010, 1451 (2010).
L. N. Suvarapu, Y. K. Seo, S. O. Baek, and V. R. Ammireddy, E-J. Chem. 9, 1288 (2012).
A. Kumar and D. Kulkarni, J. Anal. Pharm. Res. 5, 127 (2017).
A. Geersing, N. Segaud, M. G. P. van der Wijst et al., Inorg. Chem. 57, 7748 (2018).
R. K. Sodhi and S. Paul, Cancer Ther. Oncol. Int. J. 14, 25 (1019).
C. Bonaccorso, T. Marzo, and D. la Mendola, Pharmaceuticals 13, 4 (2020).
S. Sharma, M. C. Shah, N. Patel, et al., E-J. Chem. 4, 313 (2007).
K. Shivakumar, S. Shashidhar, and M. B. Halli, Russ. J. Phys. Chem. A 81, 1681 (2007).
K. Shivakumar, S. Shashidhar, and M. B. Halli, Russ. J. Phys. Chem. A 82, 2269 (2008).
J. J. Vora, D. R. Patel, A. D. Patel, et al., E-J. Chem. 6, 270 (2009).
S. Sharma, J. Ramani, and D. Patel, J. Sol. Chem. 42, 1580 (2013).
S. Sharma, J. Bhalodia, J. Ramani, and R. Patel, Chem. Eng. Commun. 200, 1009 (2013).
L. N. Tolkacheva and V. M. Nikol’skii, Russ. J. Phys. Chem. A 87, 1498 (2013).
S. S. Tulenin, S. A. Bakhteev, R. A. Yusupov, et al., Russ. J. Phys. Chem. A 87, 1771 (2013).
S. S. Sharma and M. V. Kadia, Russ. J. Phys. Chem. A 88, 2318 (2014).
S. Sharma and D. D. Patel, Chem. Sci. Rev. Lett. 4, 440 (2015).
S. Sharma and K. M. Joshi, Latin Am. Appl. Res. 45, 279 (2015).
E. A. Fedorova, L. N. Maskaeva, V. F. Markov, et al., Russ. J. Phys. Chem. A 93, 970 (2019).
B. K. Magare, B. K. Magar and M. B. Ubale, Int. Res. J. Eng. Tech. 6, 904 (2019).
Sh. Thakur, M. A. Sakhare, D. B. Jirekar, et al., Chem. J. 6, 73 (2020).
A. E. Martell and R. J. Motekaitis, Determination and Use of Stability Constants (VCH, New York, 1992).
H. M. Irving and H. S. Rossotti, J. Chem. Soc., 2904 (1954).
S. Sharma, A. Patel, J. Bhalodia, and J. Ramani, J. Iran. Chem. Res. 2, 267 (2009).
D. M. Janrao, J. Pathan, D. D. Kayande, and J. J. Mulla, Sci. Rev. Chem. Commun. 4, 11 (2014).
R. J. Motekaitis and A. E. Martell, Can. J. Chem. 60, 168 (1982).
R. J. Motekaitis and A. E. Martell, Can. J. Chem. 60, 2403 (1982).
J. J. Gongden, K. K. Gurumyen, B. A. Danja, et al., Niger. J. Chem. Res. 25, 69 (2020).
S. Glasstone, An Introduction to Electrochemistry (East-West Press, New Delhi, 1942).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare that they have no conflicts of interest.
Rights and permissions
About this article
Cite this article
Sharma, S., Chaudhari, A. Solution State Studies on Some Binary Metal Complexes of Salbutamol. Russ. J. Phys. Chem. 96, 2697–2703 (2022). https://doi.org/10.1134/S0036024422120214
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0036024422120214