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Ascorbic Acid Solubility and Thermodynamic Characteristics in Several Neat Solvents with Temperatures Ranging from 293 to 313 K

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Abstract

In this study, the solubility of ascorbic acid (AA) in eight pure solvents, including water, ethanol, methanol, 2-propanol, acetone, acetonitrile, ethyl acetate, and tetrahydrofuran, was measured over the temperature range from 293 K to 313 K. The correlation of the measured solubility data of AA was performed using three non-ideal solution models, namely the modified Apelblat equation, Buchowski–Ksiazczak model (λh equation), and the Van't Hoff model. To understand the dissolution thermodynamic of ascorbic acid, the enthalpy of dissolution ΔHsol, the entropy of dissolution ΔSsol, and the change in Gibbs free energy ΔGsol were determined by the modified forms of the Apelblat equation. The predicted results were in good agreement with the experimental solubility data. Compared to the other thermodynamic models, the computational results reveal that the modified Apelblat equation can give better correlation results for all the selected solvents. The solubility of ascorbic acid increases with rising temperature for all the adopted solvents. In general, the solubility of ascorbic acid in the four polar protic solvents obeys the following order: water > methanol > ethanol > propan-2-ol. On the other hand, the solubility of ascorbic acid in polar aprotic solvents is as follows: tetrahydrofuran > acetone > acetonitrile > ethyl acetate. For all neat solvents, the dissolution process of ascorbic acid was found to be endothermic, entropy-driven, and not spontaneous.

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Acknowledgements

This study was supported by The Ministry of Higher Education and Scientific Research of Algeria (project No. A16N01UN250320220002) and the General Directorate of Scientific Research and Technological Development (GD-SRTD).

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Authors and Affiliations

  1. Laboratory of Environmental Process Engineering, Department of Chemical Engineering, Faculty of Process Engineering, University Constantine 3 - Salah Boubnider, P.O. Box 72, 25000, Constantine, Algeria

    Leila Nemdili, Rym Guedjali, Samah Habchi, Ouahiba Koutchoukali, Aissa Dehane & Slimane Merouani

  2. Pharmaceutical Science Research Center, Constantine, Algeria

    Fatima Mameri

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  1. Leila Nemdili
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  2. Rym Guedjali
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Correspondence to Slimane Merouani.

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Nemdili, L., Guedjali, R., Habchi, S. et al. Ascorbic Acid Solubility and Thermodynamic Characteristics in Several Neat Solvents with Temperatures Ranging from 293 to 313 K. Int J Thermophys 43, 123 (2022). https://doi.org/10.1007/s10765-022-03055-4

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