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Biological and analytical applications of Schiff base metal complexes derived from salicylidene-4-aminoantipyrine and its derivatives: a review

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Abstract

Schiff bases are organic compounds referred as privileged ligands that are synthesized from the condensation of a primary amine with a carbonyl group. They are regarded as an important class of organic compounds due to their chelating properties and ability to coordinate to a wide range of transition, lanthanide, and actinide ions in different oxidation states using their nitrogen and oxygen atoms to form stable complexes. Tremendous interest has been aroused to explore the potential applications of metal complexes of various Schiff bases in confronting the challenges facing mankind such as antimicrobial resistance and environmental pollution. There has been great interest in Schiff bases and their metal complexes because of their numerous applications in organic, bioinorganic, analytical, material science, and medicinal chemistry. The presence of the azomethine group in the Schiff bases and its ability to coordinate to various metal ions is essential for these applications. This paper covers a wide range of Schiff bases synthesized from the condensation reaction involving the carbonyl group of salicylidene-4-amioantipyrine and the amine group of various organic compounds and their metal complexes which were characterized based on their numerous unique physical, chemical, and spectral properties from which different structures have been proposed. The various information was collected from researches in journals indexed by Scopus, Google Scholar, PubMed published over the years. This review provides an insight into the metal complexes of Schiff bases derived from salicylidene-4-aminoatipyrine and its derivatives and the various research works explored on its biological and analytical applications.

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Abbreviations

SOCl2 :

Thionyl chloride

PCl5 :

Phosphorus pentachloride

CH3COCl:

Acetyl chloride

LiOH:

Lithium hydroxide

NaBH4 :

Sodium borohydride

H2O2 :

Hydrogen peroxide

Fig:

Figure

UV–Vis:

Ultraviolet–visible

IR:

Infrared

FTIR:

Fourier transform infrared

NMR:

Nuclear magnetic resonance

XRD:

X-ray diffraction

DNA:

Deoxyribose nucleic acid

CT-DNA:

Calf thymus deoxyribose nucleic acid

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Authors and Affiliations

  1. Department of Chemistry, Imo State University, Owerri, Imo State, Nigeria

    Ngozi P. Ebosie

  2. Department of Chemistry, Federal University of Technology, Owerri, Imo State, Nigeria

    Martin O. C. Ogwuegbu, Gerald O. Onyedika & Fidelis C. Onwumere

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Ebosie, N.P., Ogwuegbu, M.O.C., Onyedika, G.O. et al. Biological and analytical applications of Schiff base metal complexes derived from salicylidene-4-aminoantipyrine and its derivatives: a review. J IRAN CHEM SOC 18, 3145–3175 (2021). https://doi.org/10.1007/s13738-021-02265-1

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