Skip to main content
SpringerLink
Log in

Novel metal-based antimicrobial agents of copper(II) complexes: Synthesis, spectral characterization and DNA interaction study

  • Coordination Compounds
  • Published:
Russian Journal of Inorganic Chemistry Aims and scope Submit manuscript

Abstract

Few novel mixed ligand copper(II) complexes of the type [Cu(L)(Cl)2(H2O)], [Cu(L)2]Cl2, [Cu(L)L1] and [Cu(L)(phen)H2O]Cl2 (where L is the ligand obtained from the condensation of N-(2-aminoethyl)-1,3-propanediamine with m-nitrobenzaldehyde (La)/o-chlorobenzaldehyde (Lb)/benzaldehyde (Lc)/p-methoxybenzaldehyde (Ld)/p-hydroxybenzaldehyde (Le)/furfuraldehyde (Lf)/pyrrole-2-carboxaldehyde (Lg); L1 is another ligand obtained from the condensation of anthranilic acid with salicyaldehyde; phen = 1,10-phenanthroline) have been synthesized and characterized by the spectral and analytical techniques. From these data, it is found that the ligands adopt distorted octahedral geometry on metalation with Cu(II) ion. The XRD data indicate that the complexes are polycrystalline with nanosized grains. The SEM images of [Cu(La)phen(H2O)]Cl2 and [Cu(Lf)2]Cl2 complexes show that they have leaf and cauliflower like morphology. The in vitro biological screening effects of the investigated compounds have been tested against the bacteria such as Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Pseudomonas aeruginosa and Staphylococcus aureus and fungi such as Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the well diffusion method. A comparative study of MIC values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. An electrochemical study of the copper complexes containing electron withdrawing substituted ligands reveals that they prefer to bind to DNA in Cu(II) rather than Cu(I) oxidation state.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. M. Pyle and J. K. Barton, Prog. Inorg. Chem. 38, 413 (1990).

    Article  CAS  Google Scholar 

  2. B. Macias, M. V. Villa, B. Gomez, et al., J. Inorg. Biochem. 101, 444 (2007).

    Article  CAS  Google Scholar 

  3. C. P. Raptopoulou, S. Paschalidou, A. A. Pantazaki, et al., J. Inorg. Biochem. 71, 15 (1998).

    Article  CAS  Google Scholar 

  4. P. RuÍz, R. Ortiz, L. Perelló, et al., J. Inorg. Biochem. 101, 831 (2007).

    Article  Google Scholar 

  5. C. Liu, M. Wang, T. Zhang, and H. Sun, Coord. Chem. Rev. 248, 147 (2004).

    Article  CAS  Google Scholar 

  6. M. Dizdaroglu, Free Radical Biol. Med. 10, 225 (1991).

    Article  CAS  Google Scholar 

  7. S. Belaid, A. Landreau, S. Djebbar, et al., J. Inorg. Biochem. 102, 63 (2008).

    Article  CAS  Google Scholar 

  8. J. Liu, H. Zhang, C. Chen, et al., Dalton Trans., 114 (2003).

  9. K. J. Humphreys, K. D. Karlin, and S. E. Rokita, J. Am. Chem. Soc. 124, 6009 (2002).

    Article  CAS  Google Scholar 

  10. C. A. Detmer, F. V. Pamatong, and J. R. Bocarsly, Inorg. Chem. 36, 3676 (1997).

    Article  CAS  Google Scholar 

  11. K. J. Humphreys, A. E. Johnson, K. D. Karlin, and S. E. Rokita, J. Biol. Inorg. Chem. 7, 835 (2002).

    Article  CAS  Google Scholar 

  12. S. T. Frey, H. H. Sun, N. N. Murthy, and K. Karlin, D, Inorg. Chim. Acta 242, 329 (1996).

    Article  CAS  Google Scholar 

  13. A. Garc’a-Raso, J. J. Fiol, B. Adrover, et al., J. Inorg. Biochem. 95, 77 (2003).

    Article  Google Scholar 

  14. X. Wang, H. Chao, H. Li, et al., J. Inorg. Biochem. 98, 423 (2004).

    Article  CAS  Google Scholar 

  15. A. M. Thomas, M. Nethaji, A. R. Chakravarty, J. Inorg. Biochem. 98, 1087 (2004).

    Article  CAS  Google Scholar 

  16. T. Hirohama, Y. Kuranuki, E. Ebina, et al., J. Inorg. Biochem. 99, 1205 (2005).

    Article  CAS  Google Scholar 

  17. H. Zhang, C. S. Liu, X. H. Bu, M. Yang, J. Inorg. Biochem. 99, 1119 (2005).

    Article  CAS  Google Scholar 

  18. J. R. J. Sorenson, J. Med. Chem. 19, 135 (1976).

    Article  CAS  Google Scholar 

  19. D. H. Brown, A. J. Lewis, W. E. Smith, J. W. Teape, J. Med. Chem. 23, 729 (1980).

    Article  CAS  Google Scholar 

  20. V. K. Sharma, O. P. Pandey, S. K. Sengupta, Trans. Met. Chem. 12, 509 (1987).

    Article  CAS  Google Scholar 

  21. R. Reiner, Antibiotics-an introduction, Roche Scientific Services, Switzerland, 1, 21 (1982).

    Google Scholar 

  22. M. E. Reichmann, S. A. Rice, C. A. Thomas, P. Doty, J. Am. Chem. Soc. 76, 3047 (1954).

    Article  CAS  Google Scholar 

  23. N. Raman, A. Sakthivel, K. Rajasekaran, J. Coord. Chem. 62, 1661, 2009.

    Article  CAS  Google Scholar 

  24. W. J. Geary, Coord. Chem. Rev. 7, 81 (1971).

    Article  CAS  Google Scholar 

  25. R. K. Ray, G. R. Kauffman, Inorg. Chim. Acta 173, 207 (1990).

    Article  CAS  Google Scholar 

  26. R. J. Dudley, B. J. Hathaway, J. Chem. Soc. A, 2099 (1970).

    Google Scholar 

  27. D. E. Billing, B. J. Hathaway, P. Nicholls, J. Chem. Soc. A, 1877 (1970).

    Google Scholar 

  28. A. K. Das, Medicinal Aspects of Bioinorganic Chemistry (CBS, Shahdara, Delhi, Ch. 3, 1990).

    Google Scholar 

  29. Y. Anjaneyula, R. P. Rao, Synth. React. Inorg. Met.-Org. Chem., 16, 257 (1986).

    Article  Google Scholar 

  30. L. Mishra, K. K. Upadhyay, V. K. Singh, Synth. React. Inorg. Met.-Org. Chem. 26, 23 (1996).

    Google Scholar 

  31. P. Viswanathamurthi, N. Dharmaraj, K. Natarajan, Synth. React. Inorg. Met.-Org. Chem. 30, 1273 (2000).

    CAS  Google Scholar 

  32. J. D. Ming, J. D. Epperson, J. Inorg. Biochem. 91, 46 (2002).

    Article  CAS  Google Scholar 

  33. M. Z. Wang, Z. X. Meng, B. L. Liu, et al., Inorg. Chem. Commun. 8, 368 (2005).

    Article  CAS  Google Scholar 

  34. N. Raman, A. Kulandaisamy, A. Shunmugasundaram, K. Jeyasubramanian, Trans. Met. Chem. 26, 131 (2001).

    Article  CAS  Google Scholar 

  35. Z. H. Chohan, Synth.React. Inorg. Met.-Org. Chem. 34, 833 (2004).

    CAS  Google Scholar 

  36. Z. H. Chohan, C. T. Supuran, A. Scozzafava, J. Enzym. Inhib. Med. Chem. 19, 79 (2004).

    Article  CAS  Google Scholar 

  37. H. M. Butler, A. Hurse, E. Thursky, A. Shulman, Aust. J. Expt. Biol. Med. Sci. 47, 541 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Department of Chemistry, VHNSN College, Virudhunagar, 626 001, India

    N. Raman & J. Joseph

Authors
  1. N. Raman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Joseph
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. Raman.

Additional information

The article is published in the original.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raman, N., Joseph, J. Novel metal-based antimicrobial agents of copper(II) complexes: Synthesis, spectral characterization and DNA interaction study. Russ. J. Inorg. Chem. 55, 1064–1074 (2010). https://doi.org/10.1134/S0036023610070120

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0036023610070120

Keywords

Search

Navigation