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Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid

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Abstract

2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1 mole ratio to form thiosemicarbazone H2L. Coordination compounds Cu(HL)X [X = Cl–, Br–, NO3–], Cu(H2O)(L), Ni(HL)2, Co(HL)2X [X = Cl–, Br–], and Fe(HL)2X [X = NO3–, Br–] are formed in the reactions of H2L with copper(II), nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H2O)(L) with imidazole (Im) and 3,4-dimethylpyridine (3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity in the concentration range of 15.62–1000 μg/mL. The introduction of amines into the inner sphere of copper complexes leads to an increase in the antimicrobial activity.

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Funding

The work was carried out within the framework of the State program of the Republic of Moldova (project 20.80009.5007.10).

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Authors and Affiliations

  1. State University of Moldova, MD-2009, Chisinau, Moldova

    А. P. Gulea, V. О. Graur, E. C. Diurici, Ia. I. Ulchina & V. I. Tsapkov

  2. Institute of Applied Physics, MD-2028, Chisinau, Moldova

    P. N. Bourosh

  3. State University of Medicine and Pharmacy “Nicolae Testemitanu”, MD-2001, Chisinau, Moldova

    G. G. Balan & O. S. Burduniuc

  4. National Agency of Public Health, MD-2028, Chisinau, Moldova

    O. S. Burduniuc

  5. Institute of Microbiology and Biotechnology of Academy of Sciences of Moldova, MD-2028, Chisinau, Moldova

    V. F. Rudic

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  1. А. P. Gulea
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  2. V. О. Graur
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  3. E. C. Diurici
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  4. Ia. I. Ulchina
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  5. P. N. Bourosh
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  6. G. G. Balan
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  7. O. S. Burduniuc
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  8. V. I. Tsapkov
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  9. V. F. Rudic
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Corresponding author

Correspondence to V. О. Graur.

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Gulea, А.P., Graur, V.О., Diurici, E.C. et al. Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid. Russ J Gen Chem 90, 2120–2127 (2020). https://doi.org/10.1134/S107036322011016X

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