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Comparative-biochemical analysis of lipids of blood serum lipoproteins of human and some animal species

  • Comparative and Ontogenic Biochemistry
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Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

Abstract

Lipid composition of blood serum and total lipids of low density lipoproteins (LDL) and high density lipoproteins (HDL2 and HDL3) were studied in human (donors, patients with ischemic heart disease, bronchial asthma, chronic obstructive bronchitis, as well as with a combined pathology), in mammals predisposed to atherosclerosis (pig, rabbit) and resistant to atherosclerosis (rat, mink, Arctic fox), in birds (hen, pigeon), in teleost fish (white fish, pike-perch, pike, bream, burbot) and cartilaginous fish (sturgeon, housen). It has been established that the most enriched in lipids is the blood serum of animals, particularly of cartilaginous fish. Twice lower is the lipid content in blood serum of donors than of animals. However, in the vascular, bronchopulmonary, and combined human pathologies the lipid level rises statistically significantly. In human and in animals predisposed to atherosclerosis the main mass of lipid is located in LDL, whereas in animals resistant to this disease—in HDL. The ratio of the human lipid content in LDL/HDL increases from 1.4 (in donors) to 2.7 in pathological states—in ischemic heart disease and its combination with chronic obstructive disease. In animals, a decrease of this ratio is noted from 1.0 to 0.2 in cartilaginous fish. By the example of one taxon (fish) there is established a regularity that indicates that evolution of lipoproteins occurred with an increase of the lipid amount in the “younger” LDL and with a decrease of concentration of the “older” HDL.

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References

  1. Kreps, E.M., Lipidy kletochnykh membran (Lipids of Cell Membranes), Leningrad, 1981.

  2. Regerand, T.I., Lizenko, E.I., Petrovskii, V.I., and Sidorov, V.S., Isolation of Blood Serum Lipoproteins by the Method of Sedimentation and Determination of Their Lipid Composition, Lab. Delo, 1990, no. 4, pp. 48–52.

  3. Vasilieva, O.B., Sidorov, V.S., and Lizenko, E.I., Lipid Composition of Lipoproteins of the Female Rainbow Trout Salmo gairdneri in the Annual Cycle, Vopr. Ikhtiol., 2004, vol. 44, pp. 414–418.

    Google Scholar 

  4. Lizenko, E.I., Petrovskii, V.I., Legerand, T.I., Bakhirev, A.M., and Davydov, S.A., Disturbance of Structural Lipids in Pathogenesis of Bronchial Asthma, Pulmonol., 2004, no. 4, pp. 47–50.

  5. Lisitsa, A.V., Soodaeva, S.K., Klimakov, N.A., and Chuchalin, A.G., Role of Phospholipids in Pathogenesis and Therapy of Bronchial Asthma, Pulmonol., 2006, no. 4, pp. 112–115.

  6. Kamyshnikov, V.S., Biochemical Factors of Atherogenesis in Pneumonia and Their Combination with Atherosclerosis, Izv. AN BSSR, Ser. Biol. Nauk, Minsk, 1990, Depon. in VINITI, pp. 1881–1390.

  7. Bakhirev, A.M., Lizenko, M.V., and Petrovskii, V.I., Serum Lipid Composition in Bronchitis Patients as a Predictor of Ischemic Coronary Diseases, Eur. Respir. Soc. Congr., Stockholm, 1996, p. 65.

  8. Bakhirev, A.M., Relations of Clinics and the Complete Blood Lipid Spectrum in Chronic Obstructive Bronchitis with Ischemic Heart Disease, Candidate Sci. Dissertation, St. Petersburg, 1977.

  9. Lizenko, E.I., Regerand, T.I., Lizenko, M.B., Bakhirev, A.M., Petrovskii, V.I., and Vasil’eva, O.B., Comparative Study of Structural Lipid Levels in Blood Serum and Lipoproteins of Human and Several Animals, Vopr. Biol. Med. Farm. Khim., 2004, no. 1, pp. 32–37.

  10. Ananenko, A.N., Amiraliev, S.N., Daikhin, E.I., Zvereva, V.I., Tananova, G.V., and Alieva, T.M., Clinical Significance of Determination of Serum Phospholipids and their Spectrum in Acute Pneumonia in Children of Early Age, Nerespiratornye funktsii legkikh (Non-Respiratory Functions of Lungs), Syromyatnikova, N.V., Ed., Leningrad, 1988, pp. 94–98.

  11. Ivanov, E.M., Novgorodtseva, T.P., Endakova, E.A., and Svetashev, V.I., Blood Serum Phospholipid Spectrum in Patients with Chronic Non-specific Lung Diseases in the Process of Restorative Treatment, Byull. Eksper. Biol. Med., 1989, no. 3, pp. 94–96.

  12. Nagornev, V.A., Yakovleva, O.A., and Rabinovich, O.A., Aterogenesis and Inflammation, Med. Akad. Zh., 2001, vol. 1, pp. 139–150.

    Google Scholar 

  13. Krivobok, M.N. and Tarkovskaya, O.I., Metabolism in Sires of Volga-Caspian Sturgeons and of the Stellate Sturgeon, Obmen veshchestv i biokhimiya ryb (Fish Metabolism and Biochemistry), Moscow, 1967, pp. 79–85.

  14. Lizenko, E.I., Sidorov, V.S., Luk’yanenko, V.I., Regerand, T.I., Gur’yanova, S.D., Vasil’eva, O.B., and Taksheev, S.A., Total Characteristics of Lipid Composition of Blood Serum Lipoproteins in the Sturgeons (Acipenseridae), Vopr. Ikhtiol., 1995, vol. 35,Iss. 3/4, pp. 553–557.

    CAS  Google Scholar 

  15. Simovan’yan, E.M. and Alimova, E.K., Lipid Composition of Erythrocyte Membranes and Blood Serum in Meningococcal Infection in Children, Vopr. Med. Khim., 1984, vol. 30, no. 2, pp. 28–32.

    Google Scholar 

  16. Vasiliev, A.V., Bogdanova, S.N., Varsinovich, E.A., Pogosheva, A.B., and Samsonov, M.A., Lypolytical Enzymes of Platelets and Mononuclears in Pathogenesis of Ischemic Heart Disease, Vopr. Med. Khim., 1992, vol. 38, no. 5, pp. 50–52.

    Google Scholar 

  17. Klimov, A.N. and Nikul’cheva, N.G., Metabolism of Lipids and Lipoproteins and Its Disturbances, Rukovodstvo dlya vrachei (Manual for Physicians), St. Petersburg, Moscow, Kharkov, Minsk, 1999, pp. 9–500.

  18. Doviasova, M., Strubriva, Ja., Pritchard, P.H., and Frochlich, Si., Cholesterol Esterification Rate in Plasma Depleted of Very Low and Low Density Lipoproteins is Controlled by the Proportion of HDL2 and HDL2 Subclasses Study in Hypertensive and Normal Middle Aged and Septagenarian Men, J. Lipid Res., 1992, vol. 33, pp. 1411–1419.

    Google Scholar 

  19. Lizenko, E.I., Sidorov, V.S., Regerand, T.I., Luk’yanenko, V.I., Gur’yanova, S.D., and Vasil’eva, O.B., Comparative Characteristics of Lipid Components of Blood Serum Lipoproteins of Some Cartilaginous and Bony Fish, Zh. Evol. Biokhim. Fiziol., 1998, vol. 34, pp. 641–647.

    Google Scholar 

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Authors and Affiliations

  1. Department of Facultative Therapy, Medical Faculty, Petrozavodsk State University, Petrozavodsk, Russia

    M. V. Lizenko & A. M. Bakhirev

  2. Institute of Water Problems of North, Karelian Scientific Center, Russian Academy of Sciences, Petrozavodsk, Russia

    T. I. Regerand

  3. Laboratory of Ecological Biochemistry, Institute of Biology, Karelian Scientific Center, Russian Academy of Sciences, Petrozavodsk, Russia

    E. I. Lizenko

Authors
  1. M. V. Lizenko
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  2. T. I. Regerand
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  3. A. M. Bakhirev
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  4. E. I. Lizenko
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Original Russian Text © M. V. Lizenko, T. I. Regerand, A. M. Bakhirev, E. I. Lizenko, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 5, pp. 492–500.

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Lizenko, M.V., Regerand, T.I., Bakhirev, A.M. et al. Comparative-biochemical analysis of lipids of blood serum lipoproteins of human and some animal species. J Evol Biochem Phys 44, 581–590 (2008). https://doi.org/10.1134/S0022093008050071

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  • DOI: https://doi.org/10.1134/S0022093008050071

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