Skip to main content
SpringerLink
Log in

Effect of titanium and zirconium substitutions for calcium on the formation and structure of tricalcium phosphate and hydroxyapatite

  • Published:
Inorganic Materials Aims and scope

Abstract

The effect of Ti and Zr substitutions for Ca cations on the formation of tricalcium phosphate and hydroxyapatite has been studied in a wide concentration range: from 0.1 to 20 mol %. Upon the incorporation of Ti and Zr cations into tricalcium phosphate, the major forming phase is β-tricalcium phosphate. On the addition of low substituent concentrations to hydroxyapatite, we observe the formation of a single-phase material with the apatite structure. Increasing the substituent concentration to 10–20 mol % Ti or 20 mol % Zr leads to the formation of tricalcium phosphate. The unit-cell volume of the cation-substituted tricalcium phosphates has been shown to decrease with increasing substituent concentration. In the zirconium-containing hydroxyapatites, the unit-cell volume decreases with increasing zirconium concentration, whereas the titanium-containing hydroxyapatites exhibit an opposite tendency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vallet-Regí M. and González-Calbet, J.M., Calcium phosphates as substitution of bone tissues, Prog. Solid State Chem., 2004, vol. 32, pp. 1–31.

    Article  Google Scholar 

  2. Dorozhkin, S.V., Calcium Orthophosphate-Based Bioceramics and Biocomposites, New York: Wiley, 2016.

    Book  Google Scholar 

  3. Barinov, S.M. and Komlev, V.S., Calcium phosphate bone cements (a review): I. Binder systems, Materialovedenie, 2014, no. 1, pp. 33–39.

    Google Scholar 

  4. Barinov, S.M. and Komlev, V.S., Calcium phosphate bone cements (a review): II. Composites and medical applications, Materialovedenie, 2014, no. 2, pp. 35–45.

    Google Scholar 

  5. Barinov, S.M. and Komlev, V.S., Approaches to the fabrication of calcium phosphate-based porous materials for bone tissue regeneration, Inorg. Mater., 2016, vol. 52, no. 4, pp. 339–346.

    Article  CAS  Google Scholar 

  6. Narayanan, R., Seshadri, S.K., Kwon, B.Y., and Kim, K.H., Calcium phosphate-based coatings on titanium and its alloys, J. Biomed. Mater. Res., 2008, vol. 85B, pp. 279–299.

    Article  CAS  Google Scholar 

  7. Dorozhkin, S.V., Calcium orthophosphates in dentistry (a review), J. Mater. Sci. Mater. Med., 2013, vol. 24, no. 5, pp. 1335–1363.

    Article  CAS  Google Scholar 

  8. Brunette, D.M., Tengvall, P., Textor, M., and Thomsen, P., Titanium in Medicine, Berlin: Springer, 2001.

    Book  Google Scholar 

  9. Piconi, C. and Maccauro, G., Zirconia as a ceramic biomaterial: a review, Biomaterials, 1999, vol. 20, pp. 1–25.

    Article  CAS  Google Scholar 

  10. Kannan, S., Vieira, S.I., Olhero, S.M., Torres, P.M.C., Pina, S., da Cruz e Silva, O.A.B., and Ferreira, J.M.F., Synthesis, mechanical and biological characterization of ionic doped carbonated hydroxyapatite/β-tricalcium phosphate mixtures, Acta Biomater., 2011, vol. 7, pp. 1835–1843.

    Article  CAS  Google Scholar 

  11. Šupová, M., Substituted hydroxyapatites for biomedical applications, Ceram. Int., 2015, vol. 41, no. 8, pp. 2–17.

    Google Scholar 

  12. Gol’dberg, M.A., Smirnov, V.V., Antonova, O.S., Shvorneva, L.I., Konovalov, A.A., Kudryavtsev, E.A., Smirnov, S.V., and Barinov, S.M., Effect of aging in mother liquor on the properties of magnesium-substituted calcium phosphate powders, Materialovedenie, 2016, no. 8, pp. 32–36.

    Google Scholar 

  13. Gol’dberg, M.A., Smirnov, V.V., Antonova, O.S., Shvorneva, L.I., Smirnov, S.V., Kutsev, S.V., and Barinov, S.M., Heat treatment-induced phase transformations of materials in a system of calcium phosphates and magnesium phosphates with (Ca + Mg)/P = 2, Inorg. Mater., 2016, vol. 52, no. 11, pp. 1121–1125.

    Article  Google Scholar 

  14. Efimov, A.I., Belorukova, L.P., Vasil’kova, I.V., and Chechev, V.P., Svoistva neorganicheskikh soedinenii. Spravochnik (Properties of Inorganic Compounds: A Handbook), Leningrad: Khimiya, 1983.

    Google Scholar 

  15. Godovikov, A.A., Vvedenie v mineralogiyu (Introduction to Mineralogy), Novosibirsk: Nauka, 1973, p. 256.

    Google Scholar 

  16. Kingery, W.D., Bowen, H.K., and Uhlmann, D.R., Introduction to Ceramics, New York: Wiley, 1976.

    Google Scholar 

  17. Orlova, A.I., Khainakov, S.A., Loginova, E.E., Oleneva, T.A., Garsia Granda, S., and Kurazhkovskaya, V.S., Calcium thorium phosphate (whitlockite-type mineral). Synthesis and structure refinement, Crystallogr. Rep., 2009, vol. 54, no. 4, pp. 591–597.

    Article  CAS  Google Scholar 

  18. Lameiras, F.S., Barrea, R.A., Silva, V.V., Andrade, L.H., and Macedo, F.D.A., Investigation of the incorporation of zirconium into the hydroxyapatite structure of zirconia–hydroxyapatite composites and zirconium hydroxyapatite powders, 18th Int. Cong. of Mechanical Engineering, 2005.

    Google Scholar 

  19. Pet’kov, V.I., Shchelokov, I.A., Asabina, E.A., Kurazhkovskaya, V.S., Rusakov, D.A., Pokholok, K.V., and Lazoryak, B.I., Synthesis and phase formation in M0.5(1 + x)2+FexTi2 − x(PO4)3 phosphate series, Russ. J. Inorg. Chem., 2006, vol. 51, no. 12, pp. 1855–1863.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninskii pr. 49, Moscow, 119334, Russia

    V. V. Smirnov, O. S. Antonova, S. V. Smirnov, M. A. Goldberg, V. S. Komlev & S. M. Barinov

Authors
  1. V. V. Smirnov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. S. Antonova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. V. Smirnov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. A. Goldberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. S. Komlev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. M. Barinov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. M. Barinov.

Additional information

Original Russian Text © V.V. Smirnov, O.S. Antonova, S.V. Smirnov, M.A. Goldberg, V.S. Komlev, S.M. Barinov, 2017, published in Neorganicheskie Materialy, 2017, Vol. 53, No. 12, pp. 1284–1291.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smirnov, V.V., Antonova, O.S., Smirnov, S.V. et al. Effect of titanium and zirconium substitutions for calcium on the formation and structure of tricalcium phosphate and hydroxyapatite. Inorg Mater 53, 1254–1260 (2017). https://doi.org/10.1134/S0020168517120159

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0020168517120159

Keywords

Search

Navigation