Abstract
The radioprotective properties of indralin when it is used in combination with cystamine and mexamine are studied in inbred mice and rats. The mice and rats are irradiated with γ rays emitted by 60Co at doses of 9.0 and 9.5 Gy, respectively. A combined parenteral administration of indralin and cystamine in mice at doses of 25 mg/kg each is revealed to potentiate the radioprotective properties of indralin up to a level close to the ED50 effect, while the separate application of these drugs in doses of 25 mg/kg each has no or a very weak radioprotective effect. Indralin (50 mg/kg) and mexamine (12 mg/kg) injected intraperitoneally in rats are found to almost completely eliminate the animal mortality caused by gastrointestinal acute radiation syndrome; the mortality in the control radiation group reaches 60% on the seventh day after the animals have been exposed to radiation at a dose of 9.5 Gy. However, if bone-marrow acute radiation syndrome develops under the above condition of super-lethal dose, the radioprotectors have a low radioprotective effect. Under the this condition, the combined application of indralin and mexamine in the same doses has 50% of radioprotective effect reached by applying these radioprotectors separately in double doses.
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Original Russian Text © M.V. Vasin, V.V. Antipov, S.N. Komarova, L.A. Semenova, A.A. Galkin, 2011, published in Radiatsionnaya Biologiya. Radioekologiya, 2011, Vol. 51, No. 2, pp. 243–246.
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Vasin, M.V., Antipov, V.V., Komarova, S.N. et al. Radioprotective properties of indralin combined with cystamine and mexamine. BIOPHYSICS 56, 914–916 (2011). https://doi.org/10.1134/S000635091105023X
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DOI: https://doi.org/10.1134/S000635091105023X