The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body 60Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α1-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT2 serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Vasin MV. Classification of radioprotective agents: current state and prospects of development of radiation pharmacology. Radiats. Biol. Radioekol. 2013;53(5):459-467. Russian.
Vasin MV, Ushakov IB, Kovtun VYu, Komarova SN, Semenova LA, Galkin AA, Afanas’ev RV. Antiradiation properties of emergency action radioprotector indralin applied after irradiation with partial shielding of the abdomen in rats. Radiats. Biol. Radioekol. 2008;48(2):199-202. Russian.
Vasin MV, Ushakov IB, Kovtun VYu, Komarova SN, Semenova LA, Koroleva LV, Galkin AA, Afanas’ev RV. Characteristics of radioprotective properties of the radioprotector B-190 applied after irradiation. Radiats. Biol. Radioekol. 2008;48(6):730-733. Russian.
Vasin MV, Ushakov IB, Semenova LA, Kovtun VYu. On pharmacological analysis of radioprotective effect of indraline. adiats. Biol. Radioekol. 2001;41(3):307-309. Russian.
Il’in LA, Rudnyi NM, Suvorov NN, Chernov GA, Antipov VV, Vasin MV, Davydov BI, Mikhailov PP. Indralin as an emergency action radioprotector. Antiradiation properties, pharmacology, mechanism of action, clinical manifestations. Moscow, 1994. Russian.
Kolesnichenko IS, Mikhailov LS, Boyarinov AS, Grishin AV. Preventive and therapeutic antiradiation schemes in working dogs. Veterinariya. 2005;(12):52-53. Russian.
Nefedova VV, Inzhevatkin EV, Nefedov VP. Role of S2 receptors in the stimulatory effect of serotonin on hemopoietic bone marrow stem cells. Bull. Exp. Biol. Med. 2002;133(5):419-420.
Skurikhin EG, Khmelevskaya ES, Pershina OV, Andreeva TV, Ermakova NN, Dygai AM. Effect of adrenomimetics and serotonin on polypotent stromal and hemopoietic precursors in cytostatic myelosuppression. Bull. Exp. Biol. Med. 2010;150(1):113-116.
Cosentino M, Marino F, Maestroni GJ. Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives. Front. Cell. Neurosci. 2015;9:302.
Yang M, Li K, Ng PC, Chuen CK, Lau TK, Cheng YS, Liu YS, Li CK, Yuen PM, James AE, Lee SM, Fok TF. Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells. 2007;25(7):1800-1806.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 10, pp. 460-464, October, 2016
Rights and permissions
About this article
Cite this article
Vasin, M.V., Ushakov, I.B., Kovtun, V.Y. et al. Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators. Bull Exp Biol Med 162, 466–469 (2017). https://doi.org/10.1007/s10517-017-3641-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3641-1