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The Ability of New Diaminoalkanes and Their Additive Salts, Effective in the Mouse Survival Test, to Protect the Blood System in the Bone Marrow Form of Acute Radiation Disease

  • ANIMAL AND HUMAN PHYSIOLOGY
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Abstract

A complex of parameters of the blood system of BALB/c mice was studied using alkanes symmetrically and asymmetrically replaced with heterocyclic amines, which protected 85–100% of mice after total exposure to 137Cs γ-radiation at the minimum lethal dose. The ability of substances of different structures to protect hematopoietic tissue in in vivo and in vitro experiments has been established. Differences in the rates of post-radiation repopulation of blood cells in protected mice were revealed, which are associated with the survival of the organism. It was found that the response to the effect of the investigated substances at the level of the organism (acute toxicity, anti-radiation activity, oxygen consumption by the body) and hematopoietic tissue (changes in cellularity in the hematopoietic organs and peripheral blood) depends on the structure of the substance (length of the aliphatic chain, acidic component).

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Authors and Affiliations

  1. Institute of Plant and Animal Ecology, Ural Branch, Russian Academy of Sciences, 620144, Yekaterinburg, Russia

    E. A. Tarakhtii

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620137, Yekaterinburg, Russia

    R. I. Ishmetova

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  1. E. A. Tarakhtii
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  2. R. I. Ishmetova
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Correspondence to E. A. Tarakhtii.

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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by N. Smolina

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Tarakhtii, E.A., Ishmetova, R.I. The Ability of New Diaminoalkanes and Their Additive Salts, Effective in the Mouse Survival Test, to Protect the Blood System in the Bone Marrow Form of Acute Radiation Disease. Biol Bull Russ Acad Sci 48, 340–350 (2021). https://doi.org/10.1134/S1062359021030158

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