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The Na+ pump and intracellular signaling mechanisms

  • Cell Biophysics
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Abstract

The main properties of Na+/K+-ATPase as a natural receptor for cardiotonic steroids are considered. Primary attention is focused on structural and functional differences between the α-subunit isoforms of Na+/K+-ATPase in different tissues. General information on the role of the Na+ pump in signaling cascades in kidney epithelial cells, cardiomyocytes and neurons is presented. The data obtained indicate that, in neurons, several α-isoforms of Na+/K+-ATPase possessing different sensitivity to ouabain may have different signaling functions.

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Authors and Affiliations

  1. Biological Faculty, Moscow State University, Moscow, 119992, Russia

    L. V. Karpova, E. E. Akkuratov, O. M. Brodskaya & A. A. Boldyrev

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  1. L. V. Karpova
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  2. E. E. Akkuratov
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  3. O. M. Brodskaya
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  4. A. A. Boldyrev
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Correspondence to L. V. Karpova.

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Original Russian Text © L.V. Karpova, E.E. Akkuratov, O.M. Brodskaya, A.A. Boldyrev, 2010, published in Biofizika, 2010, Vol. 55, No. 6, pp. 1022–1029.

Translation of the text provided by the authors; redaction imposed solely for comprehensibility.

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Karpova, L.V., Akkuratov, E.E., Brodskaya, O.M. et al. The Na+ pump and intracellular signaling mechanisms. BIOPHYSICS 55, 937–943 (2010). https://doi.org/10.1134/S0006350910060096

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