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Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies

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Abstract

Less than ten years ago, evidence began to accumulate about association between the changes in the composition of gut microbiota and development of human synucleinopathies, in particular sporadic form of Parkinson’s disease. We collected data from more than one hundred and thirty experimental studies that reported similar results and summarized the frequencies of detection of different groups of bacteria in these studies. It is important to note that it is extremely rare that a unidirectional change in the population of one or another group of microorganisms (only an elevation or only a reduction) was detected in the patients with Parkinson’s disease. However, we were able to identify several groups of bacteria that were overrepresented in the patients with Parkinson’s disease in the analyzed studies. There are various hypotheses about the molecular mechanisms that explain such relationships. Usually, α-synuclein aggregation is associated with the development of inflammatory processes that occur in response to the changes in the microbiome. However, experimental evidence is accumulating on the influence of bacterial proteins, including amyloids (curli), as well as various metabolites, on the α-synuclein aggregation. In the review, we provided up-to-date information about such examples.

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Fig. 1.
Fig. 2.

Abbreviations

Aβ:

β-amyloid

AD:

Alzheimer’s disease

aSyn:

α-synuclein

CNS:

central nervous system

ENS:

enteric nervous system

GIT:

gastrointestinal tract

LPS:

lipopolysaccharides

NS:

nervous system

PD:

Parkinson’s disease

PNS:

peripheral nervous system

SCFA:

short-chain fatty acids

sPD:

sporadic Parkinson’s disease

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Acknowledgments

This paper is dedicated to 300th anniversary of the St. Petersburg State University. The authors are grateful to Olga Mikhailovna Zemlyanko for critical reading of the paper.

Funding

The work was financially supported by the Russian Science Foundation, grant no. 22-74-10042.

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Authors and Affiliations

  1. Department of Genetics and Biotechnology, Saint Petersburg State University, 199034, Saint Petersburg, Russia

    Nina P. Trubitsina, Anton B. Matiiv, Tatyana M. Rogoza, Anna A. Zudilova, Mariya D. Bezgina, Galina A. Zhouravleva & Stanislav A. Bondarev

  2. St. Petersburg Branch of the Vavilov Institute of General Genetics, 198504, Saint Petersburg, Russia

    Tatyana M. Rogoza

  3. Laboratory of Amyloid Biology, Saint Petersburg State University, 199034, Saint Petersburg, Russia

    Galina A. Zhouravleva & Stanislav A. Bondarev

Authors
  1. Nina P. Trubitsina
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  2. Anton B. Matiiv
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  3. Tatyana M. Rogoza
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  4. Anna A. Zudilova
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  5. Mariya D. Bezgina
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  6. Galina A. Zhouravleva
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  7. Stanislav A. Bondarev
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Contributions

N.P.T. writing the section “Association between gut microbiome and synucleinopathies”, processing of the final version of the publication, editing of the paper; A.B.M. writing the section “αSyn protein and synucleinopathies” and subsection “Microbiota and neurodegenerative diseases”, editing of the paper; T.M.R. writing the subsection “Relationship between αSyn and GIT symptoms”, editing of the paper; A.A.Z. and M.D.B. writing the subsection “Human gut microbiome”; G.A.Z. editing of the paper; S.A.B. writing the section “Possible mechanisms of synucleinopathies development associated with dysbiosis”, preparation of illustrations, editing of the paper.

Corresponding author

Correspondence to Stanislav A. Bondarev.

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Trubitsina, N.P., Matiiv, A.B., Rogoza, T.M. et al. Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies. Biochemistry Moscow 89, 523–542 (2024). https://doi.org/10.1134/S0006297924030118

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  • DOI: https://doi.org/10.1134/S0006297924030118

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