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Blood Oxylipin Profiles as Markers of Oncological Diseases

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Abstract

Oxylipins are signal lipid molecules formed from polyunsaturated fatty acids (PUFAs) in several multienzymatic metabolic pathways, such as cyclooxygenase (COX), lipoxygenase (LOX), epoxygenase (CYP), and anandamide pathways, as well as non-enzymatically. The pathways of PUFA transformation are activated in parallel, yielding a mixture of physiologically active substances. Although the association of oxylipins with carcinogenesis had been established a long time ago, only recently analytical methods have advanced to a degree allowing detection and quantification of oxylipins from different classes (oxylipin profiles). The review describes current approaches to the HPLC-MS/MS analysis of oxylipin profiles and compares oxylipin profiles from patients with oncological diseases (breast cancer, colorectal cancer, ovarian cancer, lung cancer, prostate cancer, liver cancer). The possibility of using blood oxylipin profiles as biomarkers in oncological diseases is discussed. Understanding the patterns of PUFA metabolism and physiological activity of combinations of oxylipins will improve early diagnostics of oncological diseases and evaluation of disease prognosis.

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Abbreviations

COX:

cyclooxygenase

CYP:

cytochrome P450

DHA:

docosahexaenoic acid

EPA:

eicosapentaenoic acid

LA:

linoleic acid

LOX:

lipoxygenase

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Funding

The work was supported by the Fund for Scientific and Technological Development of Yugra, project no. 2022-05-04

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia

    Dmitry V. Chistyakov

  2. Medical Institute, Surgut State University, 628416, Surgut, Russia

    Ludmila V. Kovalenko, Maxim Y. Donnikov & Marina G. Sergeeva

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  1. Dmitry V. Chistyakov
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  2. Ludmila V. Kovalenko
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  3. Maxim Y. Donnikov
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  4. Marina G. Sergeeva
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D.V.C., M.G.S. – development of the concept and writing the article, D.V.C., M.G.S., L.V.K., M.Yu.D. – selection of the literature and editing of the article text; D.V.C., M.G.S. – revision and final approval of the article.

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Correspondence to Dmitry V. Chistyakov.

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The authors declare no conflict of interest in financial or any other sphere. This article does not contain description of studies with human participants or animals performed by any of the authors.

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Chistyakov, D.V., Kovalenko, L.V., Donnikov, M.Y. et al. Blood Oxylipin Profiles as Markers of Oncological Diseases. Biochemistry Moscow 88, 621–629 (2023). https://doi.org/10.1134/S000629792305005X

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