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Application of atomic force microscopy for characteristics of single intermolecular interactions

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Abstract

Atomic force microscopy (AFM) can be used to make measurements in vacuum, air, and water. The method is able to gather information about intermolecular interaction forces at the level of single molecules. This review encompasses experimental and theoretical data on the characterization of ligand-receptor interactions by AFM. The advantage of AFM in comparison with other methods developed for the characterization of single molecular interactions is its ability to estimate not only rupture forces, but also thermodynamic and kinetic parameters of the rupture of a complex. The specific features of force spectroscopy applied to ligand-receptor interactions are examined in this review from the stage of the modification of the substrate and the cantilever up to the processing and interpretation of the data. We show the specificities of the statistical analysis of the array of data based on the results of AFM measurements, and we discuss transformation of data into thermodynamic and kinetic parameters (kinetic dissociation constant, Gibbs free energy, enthalpy, and entropy). Particular attention is paid to the study of polyvalent interactions, where the definition of the constants is hampered due to the complex stoichiometry of the reactions.

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Abbreviations

AFM:

atomic force microscopy

APTES:

3-aminopropyltriethoxysilane

CFS:

chemical force spectroscopy

PEG:

polyethylene glycol

PPV:

plum pox virus

SMFS:

single-molecule force spectroscopy

SCFS:

single-cell force spectroscopy

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Authors and Affiliations

  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, 119071, Moscow, Russia

    I. V. Safenkova, A. V. Zherdev & B. B. Dzantiev

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  1. I. V. Safenkova
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  2. A. V. Zherdev
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  3. B. B. Dzantiev
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Correspondence to I. V. Safenkova.

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Published in Russian in Uspekhi Biologicheskoi Khimii, 2012, Vol. 52, pp. 281–314.

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Safenkova, I.V., Zherdev, A.V. & Dzantiev, B.B. Application of atomic force microscopy for characteristics of single intermolecular interactions. Biochemistry Moscow 77, 1536–1552 (2012). https://doi.org/10.1134/S000629791213010X

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