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Experimental Validation of Monte Carlo Simulation for the Leksell Gamma Knife Perfexion Using Gafchromic EBT3 Dosimetry Film and Diamond Detector T60019 PTW

  • PHYSICAL INSTRUMENTS FOR ECOLOGY, MEDICINE, AND BIOLOGY
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Abstract

This work presents experimental measurements performed using GAFChromic EBT3 dosimetry film and diamond detector T60019 to validate penEasy Monte Carlo based model developed previously for the Leksell Gamma Knife Perfexion. The relative dose profiles along X and Z coordinate axes, for each collimator size 4, 8, and 16 mm, and the relative output factors have been investigated. The penEasy model has been validated comparing the calculated output factors and dose profiles with the corresponding experimental results. The differences between the calculated output factors and the corresponding data measured with diamond detector were found to be 1.8 and 2.1% for the 8 and 4 mm collimator, respectively. Excellent agreement was found between penEasy and EBT3 results. The differences in the output factors were found to be 0.4% and −0.7% for the 8 and 4 mm collimators, respectively. The relative dose profiles were found to be in good agreement for both detectors and penEasy data. The gamma index test returns values (3%, 1 mm) < 1 for all profiles comparison calculated between penEasy and EBT3 film.

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ACKNOWLEDGMENTS

The authors would like to thank Alexey Moiseev, PhD for providing 3D printer and assistance in printing the homemade insert. Furthermore, the authors thank Andrey Golanov, MD, PhD, Gennady Gorlachev, PhD and Sergey Khromov, MSc for providing the dosimetric equipment, and Angelika Artemenkova, MSc for her assistance in performing the experiments.

Funding

This study was supported by the Russian Foundation for Basic Research and SITMA as part of research project no. 18-52-34008.

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Authors and Affiliations

  1. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409, Moscow, Russia

    T. Medjadj, A. I. Ksenofontov & V. A. Klimanov

  2. A.I. Burnazyan Federal Medical and Biophysical Center, 123182, Moscow, Russia

    V. A. Klimanov

  3. Neurosurgery Business Center (Moscow Gamma Knife Center), 125047, Moscow, Russia

    A. V. Dalechina

  4. Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department, Moscow, Russia

    Y. S. Kirpichev

  5. N.N. Blokhin National Medical Research Center of Oncology, 115478, Moscow, Russia

    Y. S. Kirpichev

Authors
  1. T. Medjadj
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  2. A. I. Ksenofontov
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  3. V. A. Klimanov
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  4. A. V. Dalechina
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  5. Y. S. Kirpichev
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Correspondence to T. Medjadj.

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Medjadj, T., Ksenofontov, A.I., Klimanov, V.A. et al. Experimental Validation of Monte Carlo Simulation for the Leksell Gamma Knife Perfexion Using Gafchromic EBT3 Dosimetry Film and Diamond Detector T60019 PTW. Instrum Exp Tech 64, 146–152 (2021). https://doi.org/10.1134/S0020441221010292

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  • DOI: https://doi.org/10.1134/S0020441221010292

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