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A role for MLH3 in hereditary nonpolyposis colorectal cancer

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Abstract

We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC families and in 288 patients suspected of having HNPCC. We identified ten different germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC. Three of the 12 also carried a mutation in MSH6.

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Figure 1: Mutation analysis of the MLH3 gene.

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Acknowledgements

We thank T.K. Sixma for alignments of the human and yeast MLH3 proteins and for mutation mapping on the E. coli MutL crystal structure. This work was supported by the Dutch Cancer Society (grant RUG 1997-1544).

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Authors and Affiliations

  1. Department of Medical Genetics, University of Groningen, Groningen, The Netherlands

    Ying Wu, Rolf H. Sijmons, Rob G.J. Mensink, Edwin Verlind, Krista A. Kooi, Charles H.C.M. Buys & Robert M.W. Hofstra

  2. Department of Gastroenterology, University of Groningen, Groningen, The Netherlands

    Maran J.W. Berends & Jan H. Kleibeuker

  3. Department of Pathology, University of Groningen, Groningen, The Netherlands

    Tineke van der Sluis, Claudia Kempinga & Harry Hollema

  4. Department of Gynecology, University of Groningen, Groningen, The Netherlands

    Ate G.J. van der Zee

Authors
  1. Ying Wu
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  2. Maran J.W. Berends
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  3. Rolf H. Sijmons
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  4. Rob G.J. Mensink
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  5. Edwin Verlind
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  6. Krista A. Kooi
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  7. Tineke van der Sluis
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  8. Claudia Kempinga
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  9. Ate G.J. van der Zee
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  10. Harry Hollema
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  11. Charles H.C.M. Buys
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  12. Jan H. Kleibeuker
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  13. Robert M.W. Hofstra
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Corresponding author

Correspondence to Robert M.W. Hofstra.

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Wu, Y., Berends, M., Sijmons, R. et al. A role for MLH3 in hereditary nonpolyposis colorectal cancer. Nat Genet 29, 137–138 (2001). https://doi.org/10.1038/ng1001-137

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  • DOI: https://doi.org/10.1038/ng1001-137

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