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The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

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Abstract

THE candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alphalocus in some cases of B-cell chronic lymphocytic leukaemias1. The protein Bcl-3 contains seven so-called ankyrin repeats. Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in 1κB proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-κB activity. No biological function has yet been described for Bcl-3, but it was noted recently2 that Bcl-3 interferes with DNA-binding of the p50 subunit of NF-κB in vitro. Here we demonstrate that Bcl-3 can aid κB site-dependent transcription in vivo by counteracting the inhibitory effects of p50/NF-κB homodimers. Bcl-3 may therefore aid activation of select NF-κB-regulated genes, including those of the human immunodeficiency virus.

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Author notes

  1. Guido Franzoso and Vincent Bours: G.F. and V.B. are joint first authors.

Authors and Affiliations

  1. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, 20892, USA

    Guido Franzoso, Vincent Bours, Sun Park, Michiyo Tomfta-Yamaguchi & Ulrich Siebenlist

  2. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Kathleen Kelly

  3. Institute of Microbiology, University of Padova Medical School, Via A. Gabelli 63, 35100, Padova, Italy

    Guido Franzoso

Authors
  1. Guido Franzoso
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  2. Vincent Bours
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  3. Sun Park
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  4. Michiyo Tomfta-Yamaguchi
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  5. Kathleen Kelly
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  6. Ulrich Siebenlist
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Franzoso, G., Bours, V., Park, S. et al. The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition. Nature 359, 339–342 (1992). https://doi.org/10.1038/359339a0

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  • DOI: https://doi.org/10.1038/359339a0

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