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The molecular genetics of embryonic pattern formation in Drosophila

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A Corrigendum to this article was published on 20 October 1988

Abstract

Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactions between transcriptional regulators', the second occurs after cellularization and depends on communication between cells. These processes may be conserved in a wide range of invertebrates and vertebrates.

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References

  1. Wilson, E. B. The Cell in Development and Heredity 3rd end (Macmillan, New York, 1925).

    Google Scholar 

  2. Lewis, E. B. Cold Spring Harb. Symp. quant. Biol. 16, 159–174 (1951).

    CAS  PubMed  Google Scholar 

  3. Lewis, E. B. Nature 276, 565–570 (1978).

    ADS  CAS  PubMed  Google Scholar 

  4. Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. & Noll, M. Cell 47, 735–746 (1986).

    CAS  PubMed  Google Scholar 

  5. Gehring, W. J. Science 236, 1245–1252 (1987).

    ADS  CAS  PubMed  Google Scholar 

  6. Gehring, W. J. & Hiromi, Y. A. Rev. Genet. 20, 147–173 (1986).

    CAS  Google Scholar 

  7. Sander, K. Adv. Insect Physiol. 12, 125–238 (1976).

    Google Scholar 

  8. Foe, V. E. & Alberts, B. M. J. cell Sci. 61, 31–70 (1983).

    CAS  PubMed  Google Scholar 

  9. Campos-Ortega, J. A. & Hartenstein, V. The Embryonic Development of Drosphila melanogaster (Springer, Berlin, 1985).

    Google Scholar 

  10. Technau, G. M. Development 100, 1–12 (1987).

    CAS  PubMed  Google Scholar 

  11. Wieschaus, E. & Gehring, W. Devl Biol. 50, 249–263 (1976).

    CAS  Google Scholar 

  12. Simcox, A. A. & Sang, J. H. Devl Biol. 97, 212–221 (1983).

    CAS  Google Scholar 

  13. Akam, M. E. Development 101, 1–22 (1987).

    CAS  PubMed  Google Scholar 

  14. Schubiger, G. & Newman, S. M. Am. Zool. 22, 47–56 (1982).

    Google Scholar 

  15. Nüsslein-Volhard, C., Frohnhöfer, H. G. & Lehmann, R. Science 238, 1675–1681 (1987).

    ADS  PubMed  Google Scholar 

  16. Frohnhöfer, H. G. & Nüsslein-Volhard, C. Nature 324, 120–125 (1986).

    ADS  Google Scholar 

  17. Berleth, T. et al. EMBO J. 7, 1749–1756 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Lehmann, R. & Nüsslein-Volhard, C. Cell 47, 141–152 (1986).

    CAS  PubMed  Google Scholar 

  19. Driever, W. & Nüsslein-Volhard, C. Cell 54, 89–98 (1988).

    Google Scholar 

  20. Driever, W. & Nüsslein-Volhard, C. Cell 54, 95–104 (1988).

    CAS  PubMed  Google Scholar 

  21. Lehmann, R. & Nüsslein-Volhard, C. Nature 329, 167–170 (1987).

    ADS  Google Scholar 

  22. Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).

    ADS  PubMed  Google Scholar 

  23. Rosenberg, U. B. et al. Nature 319, 336–339 (1986).

    ADS  CAS  Google Scholar 

  24. Tautz, D. et al. Nature 327, 383–389 (1987).

    ADS  CAS  Google Scholar 

  25. Tautz, D. Nature 332, 281–284 (1988).

    ADS  CAS  PubMed  Google Scholar 

  26. Knipple, D. et al. Nature 317, 40–44 (1985).

    ADS  CAS  PubMed  Google Scholar 

  27. Gaul, U., Seifert, E., Schuh, R. & Jäckle, H. Cell 50, 639–647 (1987).

    CAS  PubMed  Google Scholar 

  28. Gaul, U. & Jäckle, H. Cell 51, 549–555 (1987).

    CAS  PubMed  Google Scholar 

  29. Jäckle, H., Tautz, D., Schuh, R., Seifert, E. & Lehmann, R. Nature 324, 668–670 (1986).

    ADS  Google Scholar 

  30. Scott, M. P. & Carroll, S. B. Cell 51, 689–698 (1987).

    CAS  PubMed  Google Scholar 

  31. Gergen, J. P. & Butler, B. A. Genes Dev. (in the press).

  32. Howard, K. R. & Ingham, P. W. Cell 44, 949–957 (1986).

    CAS  PubMed  Google Scholar 

  33. Carroll, S. B. & Scott, M. P. Cell 45, 113–126 (1986).

    CAS  PubMed  Google Scholar 

  34. Frasch, M. & Levine, M. Genes Dev. 1, 981–995 (1987).

    CAS  PubMed  Google Scholar 

  35. Ingham, P. W. & Gergen J. P. Development (Suppl.) (in the press).

  36. Ingham, P. W., Ish-Horowicz, D. & Howard, K. R. EMBO J. 5, 1659–1665 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Howard, K. R., Ingham, P. W. & Rushlow, C. A. Genes Dev. (in the press).

  38. Martinez-Arias, A. & Lawrence, P. A. Nature 313, 639–642 (1985).

    ADS  CAS  PubMed  Google Scholar 

  39. Ingham, P. W., Baker, N. E. & Martinez-Arias, A. Nature 331, 73–75 (1988).

    ADS  CAS  PubMed  Google Scholar 

  40. Carroll, S. B. et al. Genes Dev. 2, 350–360 (1988).

    CAS  PubMed  Google Scholar 

  41. Baumgartner, S., Bopp, D., Burri, M. & Noll, M. Genes Dev. 1, 1247–1267 (1987).

    CAS  PubMed  Google Scholar 

  42. Harding, R. & Levine, M. EMBO J. 7, 205–214 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Ingham, P. W. & Martinez-Arias, A. Nature 324, 592–597 (1986).

    ADS  CAS  PubMed  Google Scholar 

  44. Gergen, J. P., Coulter, D. & Wieschaus, E. Symp. Soc. dev. Biol. 44, 195–220 (1986).

    Google Scholar 

  45. Baker, N. E. EMBO J. 6, 1765–1773 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Martinez-Arias, A., Baker, N. E. & Ingham, P. W. Development 103, 157–170 (1988).

    CAS  PubMed  Google Scholar 

  47. Morata, G. & Lawrence, P. A. Devl Biol. 56, 227–240 (1977).

    CAS  Google Scholar 

  48. DiNardo, S., Sher, E., Heemskerk-Jongens, J., Kassis, J. A. & O'Farrell, P. H. Nature 332, 604–609 (1988).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  49. Rijsewijk, F. et al. Cell 50, 649–657 (1987).

    CAS  PubMed  Google Scholar 

  50. Tomlinson, A. & Ready, D. F. Devl Biol. 120, 366–376 (1987).

    CAS  Google Scholar 

  51. Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55–63 (1988).

    ADS  Google Scholar 

  52. Anderson, K. V. Trends Genet. 3, 91–97 (1987).

    Google Scholar 

  53. Levine, M. Cell 52, 785–786 (1988).

    CAS  PubMed  Google Scholar 

  54. DeLotto, R. & Spierer, P. Nature 323, 688–692 (1986).

    ADS  CAS  PubMed  Google Scholar 

  55. Steward, R. et al. Cold Spring Harbor Symp. quant. Biol. 50, 223–228 (1985).

    CAS  PubMed  Google Scholar 

  56. Hashinoto, C., Hudson, K. L. & Anderson, K. V. Cell 52, 269–279 (1988).

    Google Scholar 

  57. Wakimoto, B. T., Turner, F. R. & Kaufman, T. C. Devl Biol. 102, 147–172 (1984).

    CAS  Google Scholar 

  58. Irish, V. F. & Gelbart, W. M. Genes Dev. 1, 868–879 (1987).

    CAS  PubMed  Google Scholar 

  59. Simpson, P. Genetics 105, 615–632 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Thomas, J. B., Crews, S. T. & Goodman, C. S. Cell 52, 133–141 (1988).

    CAS  PubMed  Google Scholar 

  61. Crews, S. T., Thomas, J. B. & Goodman, C. S. Cell 52, 143–151 (1988).

    CAS  PubMed  Google Scholar 

  62. Doyle, H. J., Harding, K., Hoey, T. & Levine, M. Nature 323, 76–79 (1986).

    ADS  CAS  PubMed  Google Scholar 

  63. Rushlow, C., Frasch, M., Doyle, H. & Levine, M. Nature 330, 583–586 (1987).

    ADS  CAS  PubMed  Google Scholar 

  64. St Johnston, R. D. & Gelbart, W. M. EMBO J. 6, 2785–2791 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Padgett, R. W., St Johnston, R. D. & Gelbart, W. M. Nature 325, 81–84 (1987).

    ADS  CAS  PubMed  Google Scholar 

  66. Knust, E. et al. EMBO J. 6, 761–766 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Thisse, B., Stoetzel, C., Gorostiza-Thisse, C. & Perrin-Schmitt, F. EMBO J. 7, 2175–2184 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Boulay, J. L., Dennefeld, C. & Alberga, A. Nature 330, 395–38 (1987).

    ADS  CAS  PubMed  Google Scholar 

  69. Campos-Ortega, J. A. Trends Neurosci. 8, 245–250 (1985).

    Google Scholar 

  70. Artavanis-Tsakonas, S. Trends Genet. 4, 95–100 (1988).

    CAS  PubMed  Google Scholar 

  71. Doe, C. Q. & Scott, M. P. Trends Neurosci. 3, 101–106 (1988).

    Google Scholar 

  72. Cabrera, C. V., Martinez-Arias, A. & Bate, M. Cell 50, 425–433 (1987).

    CAS  PubMed  Google Scholar 

  73. Doe, C. Q., Smouse, D. & Goodman, C. S. Nature 33, 376–378 (1988).

    ADS  Google Scholar 

  74. Doe, C. Q., Hiromi, Y., Gehring, W. J. & Goodman, C. S. Science 239, 170–175 (1988).

    ADS  CAS  PubMed  Google Scholar 

  75. Weeks, D. C. & Melton, D. A. Cell 51, 861–867 (1987).

    CAS  PubMed  Google Scholar 

  76. Evans, R. M. & Hollenberg, S. M. Cell 52, 1–3 (1988).

    CAS  PubMed  Google Scholar 

  77. Nasmyth, K. & Shore, D. Science 237, 1163–1170 (1987).

    ADS  Google Scholar 

  78. Page, D. C. et al. Cell 51, 1091–1104 (1987).

    CAS  PubMed  Google Scholar 

  79. Gaunt, S. J., Sharpe, P. T. & Duboule, D. Development (Suppl.) (in the press).

  80. Bogaert, T., Brown, N. & Wilcox, M. Cell 51, 929–940 (1987).

    CAS  PubMed  Google Scholar 

  81. Snow, P. M. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).

  82. Kimelmann, D. & Kirschner, M. Cell 51, 869–877 (1987).

    Google Scholar 

  83. Slack, J. M. W., Darlington, B. G., Heath, J. K. & Godsave, S. Nature 326, 197–200 (1987).

    ADS  CAS  PubMed  Google Scholar 

  84. Wilkinson, D. G., Peters, G., Dickson, C. & MacMahon, A. P. EMBO J. 691–695 (1988).

  85. Wilkinson, D. G., Bailes, J. A. & McMahon, A. P. Cell 50, 79–88 (1987).

    CAS  PubMed  Google Scholar 

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  1. Molecular Embryology Laboratory, ICRF Developmental Biology Unit, Department of Zoology, South Parks Road, Oxford, OXI 3PS, UK

    P. W. Ingham

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  1. P. W. Ingham
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Ingham, P. The molecular genetics of embryonic pattern formation in Drosophila. Nature 335, 25–34 (1988). https://doi.org/10.1038/335025a0

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