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Drosophila melanogaster as a Model of Developmental Genetics: Modern Approaches and Prospects

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Abstract

For more than a 100 years, the fruit fly Drosophila melanogaster has successfully served as a universal model in various genetic studies, including studies into the genetic control of individual development. To date, a whole arsenal of reverse genetics methods has been developed for Drosophila, making it quite easy to manipulate its genome, which allows Drosophila to be considered one of the most powerful models of developmental genetics. The review considers the main modern methods for studying the expression and function of genes in Drosophila and the prospects for their use.

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ACKNOWLEDGMENTS

I thank Dr. Sci. (Biol.) O.B. Simonova for fruitful discussion of the article.

Funding

The work was carried out as part of the Molecular Genetic Mechanisms of Genome Instability and Mutagenesis in Animals and Humans program of the Faculty of Biology of Moscow State University (AAAA-A16-116021660038-4).

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  1. Faculty of Biology, Moscow State University, 119234, Moscow, Russia

    L. N. Nefedova

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Translated by N. Smolina

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Nefedova, L.N. Drosophila melanogaster as a Model of Developmental Genetics: Modern Approaches and Prospects. Russ J Dev Biol 51, 201–211 (2020). https://doi.org/10.1134/S1062360420040050

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