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Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

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Abstract

Many of the actions previously attributed to pituitary-derived growth hormone are mediated by polypeptide growth factors1–3. These include the insulin-like growth factors I and II (IGF-I and IGF-II)4–6, which are members of the insulin family of proteins7. We report here the chromosomal mapping of the human genes for IGF-I and IGF-II. IGF-II maps to the short arm of chromosome 11, which also contains the gene for insulin8 and the proto-oncogene c-Ha-ras1 (ref. 9). IGF-I maps to chromosome 12, which is evolutionarily related to chromosome 11 and carries the gene for the proto-oncogene c-Ki-ras2 (refs 10,44). We have also localized the human gene for an unrelated polypeptide hormone, epidermal growth factor, to chromosome 4q, in the same region as another specialized growth factor, T–cell growth factor11. We speculate that these map assignments reflect the existence of gene families involved in growth control.

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Authors and Affiliations

  1. Department of Human Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510, USA

    Jane E. Brissenden & Uta Francke

  2. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Axel Ullrich

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  1. Jane E. Brissenden
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  2. Axel Ullrich
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  3. Uta Francke
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Brissenden, J., Ullrich, A. & Francke, U. Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor. Nature 310, 781–784 (1984). https://doi.org/10.1038/310781a0

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