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Epidermal Growth Factor

  • Chapter
Tissue Growth Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 57))

Abstract

During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extract fractions into newborn mice produced developmental changes that could not be ascribed to nerve growth factor. These changes included precocious opening of the eyelids (7 days compared to the usual 14 days) and a similar early eruption of the incisors. Using these gross anatomical changes as an assay, Cohen (1962) proceeded to isolate the active factor — a polypeptide which he termed epidermal growth factor (EGF).

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  1. G. Carpenter
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  1. Fels Research Institute and Department of Pathology, Temple University School of Medicine, Health Sciences Center, Philadelphia, PA, 19140, USA

    Renato Baserga M.D. (Senior Investigator) (Senior Investigator)

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Carpenter, G. (1981). Epidermal Growth Factor. In: Baserga, R. (eds) Tissue Growth Factors. Handbook of Experimental Pharmacology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67986-5_3

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