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Primary structure of a murine transplantation antigen

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Abstract

A radiochemical technique has been used to determine the primary structure of a murine H-2Kb molecule, a 346-residue glycoprotein subunit attached to a 99-residue β2-microglobulin subunit. Comparison of this structure with those available for other murine H–2 antigens and human HLA molecules suggests an evolutionary origin of MHC products.

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References

  1. Paul, W. E. & Benacerraf, B. Science 195, 1293–1299 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Klein, J. Science 203, 516–521 (1979).

    Article  ADS  CAS  Google Scholar 

  3. Klein, J. Biology of the Mouse Histocompatibility-2 Complex (Springer, New York, 1975).

    Book  Google Scholar 

  4. Snell, G. D., Dausset, J. & Nathenson, S. G. Histocompatibility (Academic, New York, 1976).

    Google Scholar 

  5. Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 51–177 (1979).

    Article  CAS  Google Scholar 

  6. Shearer, G. M. & Schmidt-Verhulst, A. M. Adv. Immun. 25, 55–91 (1977).

    Article  CAS  Google Scholar 

  7. Klein, J. Adv. Immun. 26, 55–146 (1978).

    Article  CAS  Google Scholar 

  8. Festenstein, H. & Démant, P. Curr. Topics Immun. 9 (1979).

  9. Nathenson, S. G., Uehara, H., Ewenstein, B., Kindt, T. J. & Coligan, J. E. A. Rev. Biochem. (in the press).

  10. Strominger, J. L. et al. in The Role of the Major Histocompatibility Complex in Immunobiology (eds Benacerraf, B. & Cantor, H.) (Garland, New York, 1981).

    Google Scholar 

  11. Vitetta, E. S. & Capra, J. D. Adv. Immun. 26, 147–193 (1978).

    Article  CAS  Google Scholar 

  12. Uehara, H. et al. Biochemistry 19, 6182–6188 (1980).

    Article  CAS  Google Scholar 

  13. Martinko, J. M. et al. Biochemistry 19, 6188–6193 (1980).

    Article  CAS  Google Scholar 

  14. Nairn, R., Nathenson, S. G. & Coligan, J. E. Eur. J. Immun. 10, 495–503 (1980).

    Article  CAS  Google Scholar 

  15. Coligan, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 77, 1134–1138 (1980).

    Article  ADS  CAS  Google Scholar 

  16. Kimball, E. S., Nathenson, S. G. & Coligan, J. E. Biochemistry (in the press).

  17. Maloy, W. L., Nathenson, S. G. & Coligan, J. E. J. biol. Chem. 256, 2863–2872 (1981).

    CAS  PubMed  Google Scholar 

  18. Ewenstein, B. M., Freed, J. H., Mole, L. E. & Nathenson, S. G. Proc. natn. Acad. Sci. U.S.A. 73, 915–918 (1976).

    Article  ADS  CAS  Google Scholar 

  19. Ewenstein, B. M. et al. Proc. natn. Acad. Sci. U.S.A. 75, 2909–2913 (1978).

    Article  ADS  CAS  Google Scholar 

  20. Coligan, J. E. et al. Molec. Immun. 16, 3–8 (1979).

    Article  CAS  Google Scholar 

  21. Uehara, H. et al. Biochemistry 19, 306–315 (1980).

    Article  CAS  Google Scholar 

  22. Gates, F. T. III, Coligan, J. E. & Kindt, T. J. Proc. natn. Acad. Sci. U.S.A. 78, 554–558 (1981).

    Article  ADS  CAS  Google Scholar 

  23. Kindt, T. J., Coligan, J. E., Uehara, H. & Nathenson, S. G. Proc. int. Conf. Chemical Synthesis of Peptides and Proteins (Elsevier, Amsterdam, in the press).

  24. Schwartz, B. D., Kato, K., Cullen, S. E. & Nathenson, S. G. Biochemistry 12, 2157–2164 (1973).

    Article  CAS  Google Scholar 

  25. Henriksen, O., Robinson, E. A. & Appella, E. Proc. natn. Acad. Sci. U.S.A. 75, 3322–3326 (1978).

    Article  ADS  CAS  Google Scholar 

  26. Rogers, M. J., Robinson, E. A. & Appella, E. J. biol. Chem. 254, 1126–1133 (1979).

    Google Scholar 

  27. Freed, J. H., Sears, D. L., Brown, J. L. & Nathenson, S. G. Molec. Immun. 16, 9–21 (1979).

    Article  CAS  Google Scholar 

  28. Silver, J. & Hood, L. Nature 256, 63–64 (1975).

    Article  ADS  CAS  Google Scholar 

  29. Capra, J. D., Vitetta, E. S., Klapper, D. G., Uhr, J. W. & Klein, J. Proc. natn. Acad. Sci. U.S.A. 73, 3661–3664 (1976).

    Article  ADS  CAS  Google Scholar 

  30. Brown, J. L., Kato, K., Silver, J. & Nathenson, S. G. Biochemistry 13, 3174–3178 (1974).

    Article  CAS  Google Scholar 

  31. Maloy, W. L., Hämmerling, G., Nathenson, S. G. & Coligan, J. E. J. immun. Meth. 37, 287–299 (1980).

    Article  CAS  Google Scholar 

  32. Kimball, E. S., Maloy, W. L., Martinko, J. M., Nathenson, S. G. & Coligan, J. E. Molec. Immun. 17, 1283–1291 (1980).

    Article  CAS  Google Scholar 

  33. Coligan, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3390–3394 (1978).

    Article  ADS  CAS  Google Scholar 

  34. Kimball, E. S., Coligan, J. E. & Kindt, T. J. Immunogenetics 8, 201–211 (1979).

    Article  CAS  Google Scholar 

  35. Gates, F. T. III, Kimball, E. S. & Coligan, J. E. (in preparation).

  36. Michaelson, J., Rothenberg, E. & Boyse, E. A. Immunogenetics 11, 93–95 (1980).

    Article  CAS  Google Scholar 

  37. Goding, J. W. & Walker, I. D. Proc. natn. Acad. Sci. U.S.A. 77, 7395–7399 (1980).

    Article  ADS  CAS  Google Scholar 

  38. Robinson, P. J., Graf, L. & Sege, K. Proc. natn. Acad. Sci. U.S.A. (in the press).

  39. Nathenson, S. G. & Shimada, A. Transplantation 6, 662–663 (1968).

    Article  Google Scholar 

  40. Mann, D. L., Rogentine, G. N. Jr, Fahey, J. L. & Nathenson, S. G. Nature 217, 1180–1181 (1968).

    Article  ADS  CAS  Google Scholar 

  41. Dickerson, R. E. & Geis, I. The Structure and Action of Proteins, 28 (Harper & Row, London, 1969).

    Google Scholar 

  42. Tomita, M., Furthmayr, H. & Marchesi, V. T. Biochemistry 17, 4756–4770 (1978).

    Article  CAS  Google Scholar 

  43. Rogers, J. et al. Cell 20, 303–312 (1980).

    Article  CAS  Google Scholar 

  44. Robb, R. J., Terhorst, C. & Strominger, J. L. J. biol. Chem. 253, 5319–5324 (1978).

    CAS  Google Scholar 

  45. Walsh, F. S. & Crumpton, M. J. Nature 269, 307–311 (1977).

    Article  ADS  CAS  Google Scholar 

  46. Rothbard, J. B., Hopp, T. P., Edelman, G. M. & Cunningham, B. A. Proc. natn. Acad. Sci. U.S.A. 77, 4239–4243 (1980).

    Article  ADS  CAS  Google Scholar 

  47. Pober, J. S., Guild, B. C. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 75, 6002–6004 (1978).

    Article  ADS  CAS  Google Scholar 

  48. Orr, H. T., Lancet, D., Robb, R. J., Lopez de Castro, J. A. & Strominger, J. L. Nature 282, 266–270 (1979).

    Article  ADS  CAS  Google Scholar 

  49. Trägårdh, L., Rask, L., Wiman, K., Fohlman, J. & Peterson, P. A. Proc. natn. Acad. Sci. U.S.A. 77, 1129–1133 (1980).

    Article  ADS  Google Scholar 

  50. Coligan, J. E. et al. Transplantn Proc. (in the press).

  51. Kabat, E. A., Wu, T. T. & Bilofsky, H. Sequences of Immunoglobulin Chains (NIH Publ. No. 80-2008, (1979).

    Google Scholar 

  52. Nisizawa, T., Ewenstein, B. M., Uehara, H., McGovern, D. & Nathenson, S. G. Immunogenetics 12, 33–44 (1981).

    Article  CAS  Google Scholar 

  53. Nairn, R., Yamaga, K. & Nathenson, S. G. A. Rev. Genet. 14, 241–277 (1980).

    Article  CAS  Google Scholar 

  54. Martinko, J. M., Halpern, R., Aldersberg, J. R. & Nathenson, S. G. Molec. Immun. (in the press).

  55. Ewenstein, B. M. et al. Immunogenetics 11, 383–396 (1980).

    Article  CAS  Google Scholar 

  56. Uehara, H., Coligan, J. E. & Nathenson, S. G. Biochemistry (submitted).

  57. Nathenson, S. G. et al. in Current Trends in Histocompatibility (eds Ferrone, S. & Reisfeld, R. A.) (Plenum, New York, in the press).

  58. Trägårdh, L., Wiman, K., Rask, L. & Peterson, P. A. Biochemistry 18, 1322–1328 (1979).

    Article  Google Scholar 

  59. Orr, H. T., Lopez de Castro, J. A., Parham, P., Ploegh, H. L. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 76, 4395–4399 (1979).

    Article  ADS  CAS  Google Scholar 

  60. Orr, H. T., Lopez de Castro, J. A., Lancet, D. & Strominger, J. L. Biochemistry 18, 5711–5720 (1979).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Immunogenetics, Building 8, Room 100, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA

    J. E. Coligan & T. J. Kindt

  2. Departments of Microbiology and Immunology and Cell Biology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    H. Uehara, J. Martinko & S. G. Nathenson

Authors
  1. J. E. Coligan
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  2. T. J. Kindt
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  3. H. Uehara
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  4. J. Martinko
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  5. S. G. Nathenson
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Coligan, J., Kindt, T., Uehara, H. et al. Primary structure of a murine transplantation antigen. Nature 291, 35–39 (1981). https://doi.org/10.1038/291035a0

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  • DOI: https://doi.org/10.1038/291035a0

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