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Histamine induces release of an eosinophil immobilising factor from mononuclear cells

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Abstract

LIBERATION of factors chemotactic for eosinophil granulocytes is often associated with the release of histamine from mast cells and basophils. This is true for the eosinophil chemotactic factor of anaphylaxis (ECF-A), which is secreted together with histamine from mast cells and basophils1. It also applies to the generation of chemotactic factors by the activation of complement (C), which leads to the liberation of anaphylatoxin2. Therefore, it was of interest to study whether histamine had any effect on the migration of eosinophils towards chemotactic attractants. We describe here a factor which inhibits the migration of eosinophil granulocytes and which is released from mononuclear cells upon incubation with histamine.

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Authors and Affiliations

  1. Institut für Immunologie und Serologie, 69 Heidelberg, Postfach 103060, Germany

    ECKHARD KOWNATZKI, GERD TILL, MICHAEL GAGELMANN, GUDRUN TERWORT & DIETHARD GEMSA

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  1. ECKHARD KOWNATZKI
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  2. GERD TILL
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  3. MICHAEL GAGELMANN
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  4. GUDRUN TERWORT
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  5. DIETHARD GEMSA
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KOWNATZKI, E., TILL, G., GAGELMANN, M. et al. Histamine induces release of an eosinophil immobilising factor from mononuclear cells. Nature 270, 67–69 (1977). https://doi.org/10.1038/270067a0

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  • DOI: https://doi.org/10.1038/270067a0

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